Experimental protocols of in vitro formulation screening should include both low and high dilution levels of physiological relevance. The study of excipient interaction and estimation of supersaturation allows the identification of formulations that are prone to drug precipitation.
Future dilution tests should include a formulation-to-water ratio of roughly 1:5 (w/w), which is in the proximity of the individual threshold concentration. Additional dilutions may be tested below and clearly above this value to reflect the physiological dilution process.
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