While the characterization of materials by NMR is hugely important in the physical and biological sciences, it also plays a vital role in medical imaging. This success is all the more impressive because of the inherently low sensitivity of the method. We establish here that [Ir(H)2(IMes)(py)3]Cl undergoes both pyridine (py) loss as well as the reductive elimination of H2. These reversible processes bring para-H2 and py into contact in a magnetically coupled environment, delivering an 8100-fold increase in 1H NMR signal strength relative to non-hyperpolarized py at 3 T. An apparatus that facilitates signal averaging has been built to demonstrate that the efficiency of this process is controlled by the strength of the magnetic field experienced by the complex during the magnetization transfer step. Thermodynamic and kinetic data combined with DFT calculations reveal the involvement of [Ir(H)2(η2-H2)(IMes)(py)2]+, an unlikely yet key intermediate in the reaction. Deuterium labeling yields an additional 60% improvement in signal, an observation that offers insight into strategies for optimizing this approach.
The two-color (1+1′) threshold photoelectron spectra of naphthalene in a supersonic free jet have been recorded via nine vibronic levels of the S1 electronic state up to about 1420 cm−1 above the S1 band origin. The threshold photoelectron spectra recorded via the S1 band origin and via totally symmetric ag vibronic levels show significant intensity in Δν=+1 transitions in nontotally symmetric vibrations having b1g symmetry indicating that the ionization transition gains significant intensity through a vibronic coupling mechanism between the two lowest doublet cationic states. The strongest departure from the expected Δν=0 propensity in the threshold photoelectron spectra occurs through excitation of the totally symmetric 8 mode having ag symmetry indicating that a considerable displacement occurs along the normal coordinate of this 8 mode upon ionization from the S1 state. The superior resolution of the threshold photoelectron technique over conventional photoelectron methods has allowed accurate values for the fundamental vibrational frequencies of naphthalene in its ground cationic state to be determined and it has also allowed a more rigorous investigation of the vibronic coupling mechanism that occurs between the two lowest doublet cationic states. Moreover, an improved value for the adiabatic ionization energy of naphthalene of 65 687±7 cm−1 (8.1442±0.0009 eV) has been determined.
We report on a strategy for using SABRE (signal amplification by reversible exchange) for polarizing 1H and 13C nuclei of weakly interacting ligands which possess biologically relevant and nonaromatic motifs. We first demonstrate this via the polarization of acetonitrile, using Ir(IMes)(COD)Cl as the catalyst precursor, and confirm that the route to hyperpolarization transfer is via the J-coupling network. We extend this work to the polarization of propionitrile, benzylnitrile, benzonitrile, and trans-3-hexenedinitrile in order to assess its generality. In the 1H NMR spectrum, the signal for acetonitrile is enhanced 8-fold over its thermal counterpart when [Ir(H)2(IMes)(MeCN)3]+ is the catalyst. Upon addition of pyridine or pyridine-d5, the active catalyst changes to [Ir(H)2(IMes)(py)2(MeCN)]+ and the resulting acetonitrile 1H signal enhancement increases to 20- and 60-fold, respectively. In 13C NMR studies, polarization transfers optimally to the quaternary 13C nucleus of MeCN while the methyl 13C is hardly polarized. Transfer to 13C is shown to occur first via the 1H–1H coupling between the hydrides and the methyl protons and then via either the 2J or 1J couplings to the respective 13Cs, of which the 2J route is more efficient. These experimental results are rationalized through a theoretical treatment which shows excellent agreement with experiment. In the case of MeCN, longitudinal two-spin orders between pairs of 1H nuclei in the three-spin methyl group are created. Two-spin order states, between the 1H and 13C nuclei, are also created, and their existence is confirmed for Me13CN in both the 1H and 13C NMR spectra using the Only Parahydrogen Spectroscopy protocol.
The addition of water to dihydrolevoglucosenone (Cyrene) creates a solvent mixture with highly unusual properties and the ability to specifically and efficiently solubilize a wide range of organic compounds, notably, aspirin, ibuprofen, salicylic acid, ferulic acid, caffeine, and mandelic acid. The observed solubility enhancement (up to 100-fold) can be explained only by the existence of microenvironments mainly centered on Cyrene’s geminal diol. Surprisingly, the latter acts as a reversible hydrotrope and regulates the polarity of the created complex mixture. The possibility to tune the polarity of the solvent mixture through the addition of water, and the subsequent generation of variable amounts of Cyrene’s geminal diol, creates a continuum of green solvents with controllable solubilization properties. The effective presence of microheterogenieties in the Cyrene/water mixture was adequately proven by (1) Fourier transform infrared/density functional theory showing Cyrene dimerization, (2) electrospray mass-spectrometry demonstrating the existence of dimers of Cyrene’s geminal diol, and (3) the variable presence of single or multiple tetramethylsilane peaks in the 1 H NMR spectra of a range of Cyrene/water mixtures. The Cyrene–water solvent mixture is importantly not mutagenic, barely ecotoxic, bioderived, and endowed with tunable hydrophilic/hydrophobic properties.
Competition between cation-π interactions and intermolecular hydrogen bonds inalkali metal ion-phenol clusters. II. Phenol trimer Structures and rearrangement reactions of 4 -aminophenol ( H 2 O ) 1 + and 3 -aminophenol ( H 2 O ) 1 + clusters J. Chem. Phys. 123, 074320 (2005); 10.1063/1.2008255 The energetics and structural properties of diazomethyl (HCNN) and cyanomidyl (HNCN) radicals and their related cations and anions from ab initio calculations J. Chem. Phys. 122, 064316 (2005); 10.1063/1.1844314 Intermolecular vibrations of the jet-cooled 2-pyridone2-hydroxypyridine mixed dimer, a model for tautomeric nucleic acid base pairsThe phenol•N 2 complex cation has been studied with a combination of two-color resonant zero kinetic energy ͑ZEKE͒ and mass analyzed threshold ionization ͑MATI͒ spectroscopies to probe the interaction of a polar cation with a quadrupolar solvent molecule. Extended vibrational progressions are observed in three modes which are assigned as the in-plane bend ͑35 cm Ϫ1 ͒, the stretch ͑117 cm Ϫ1 ͒, and in-plane wag ͑130 cm Ϫ1 ͒ intermolecular vibrations, and are consistent with a structure where the N 2 forms a directional bond to the phenol OH group in the plane of the aromatic ring. Ab initio calculations at the UMP2/6-31G*, UHF/cc-pVDZ, and UMP2/cc-pVDZ levels of theory support this assignment. The spectra also provide a value for the adiabatic ionization energy (67 423 cm Ϫ1 Ϯ4.5 cm Ϫ1 ) and an estimate of the dissociation energy of the cluster (1650 Ϯ20 cm Ϫ1 ) which illustrate that the quadrupolar nitrogen molecule binds considerably more strongly to the phenol cation than a rare gas atom. These results constitute the first report of an aromatic•N 2 complex where the interaction can be described in terms of weak hydrogen bonding, rather than in terms of a van der Waals bond to the -system of the benzene ring.
This work combines high level ab initio calculations with multidimensional Franck-Condon calculations to refine and augment previous assignments of the lower wavenumber region of the A (1)B(2) <-- X (1)A(1) band system of fluorobenzene. The strength of the assignment has been greatly assisted by the use of zero electron kinetic energy spectroscopy in a series of pump-probe experiments where the response of the molecule to selective excitation in specific modes prior to ionization has been studied. The net result of this analysis is the reassignment of 7 of the 12 previously assigned bands in the region below about 1000 cm(-1) using a strategy that aims to trace the origins of excited state normal modes of fluorobenzene to the well-known Wilson modes of benzene by taking full account of the Duschinsky mixing that accompanies electronic excitation. Duschinsky normal mode analyses of the ground and first excited states of fluorobenzene as well as the electronic ground state of fluorobenzene cation have shown that the common use of the benzene Wilson notation to describe normal modes of this prototypical benzene derivative is highly questionable, particularly following electronic excitation and ionization.
Articles you may be interested inTwo-dimensional laser induced fluorescence spectroscopy of van der Waals complexes: Fluorobenzene-Ar n (n = 1,2) J. Chem. Phys. 136, 134309 (2012); 10.1063/1.3697474 X-ray photoelectron spectroscopy study of polyimide thin films with Ar cluster ion depth profiling J. Vac. Sci. Technol. A 28, L1 (2010); 10.1116/1.3336242Low lying electronic states of rare gas-oxide anions: Photoelectron spectroscopy of complexes of O − with Ar, Kr, Xe, and N 2 Fragmentation energetics and dynamics of fluorobenzeneAr n (n=1-3) clusters studied by mass analyzed threshold ionization spectroscopy In this work, the molecules styrene (ST) and phenylacetylene (PA), as well as their argon complexes ST -Ar and PA-Ar, have been investigated with (1 + 1') resonance enhanced multiphoton ionization (REMPI) threshold photoelectron spectroscopy (TES). The first adiabatic ionization energies of ST, PA, ST -Ar, and PA-Ar have been measured as 68 267 ± 5, 71175±5, 68 151 ±5, and 71 027±5 cm-I , respectively. For both ST-Ar and PA-Ar, the first photoelectron band shows structure in the lowest frequency van der Waals (vdW) bending mode in the ground ionic state, with VydW being measured as 15 cm-I in each case. For each molecule excitation to a particular vibrational level of the S I state followed by ionization, allows structure in that mode to be observed in the threshold photoelectron spectrum. This has been achieved for three modes in both styrene and phenylacetylene. The experimental ionic vibrational frequencies thus obtained, have been compared with those known for the So and S I states.a)IMS Visiting Fellow. Permanent address:
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