BACKGROUND AND OBJECTIVES:Tramadol blocks somatosensory potentials in vitro and may be associated to local anesthetics to improve analgesic quality. This study aimed at evaluating whether tramadol changes lidocaine motor block regression in two different concentrations. METHOD: Male Wistar rats weighing 250 to 300 g were submitted to sciatic nerve block guided by percutaneous nerve stimulation. Animals were distributed in four groups (n = 5 per group): 2% lidocaine (GI), 0.5% lidocaine (GII), 2% lidocaine/1.25 tramadol (GIII), 0.5% lidocaine/1.25 tramadol (GIV). Partial and total motor block regression times were evaluated. RESULTS: Al animals had total motor block when awakening from anesthesia, which has totally regressed during the observation period. Total regression time of 2% lidocaine was 41 ± 1.71 minutes, 0.5% lidocaine was 25.26 ± 0.83 minutes, 2% lidocaine/tramadol was 46.06 ± 0.88 minutes and 0.5% lidocaine/ tramadol was 36.15 ± 1.18 minutes. The association of 0.5% lidocaine and 1.25 mg tramadol was more effective as compared to 0.5% lidocaine alone. Data are presented in mean ± mean standard error (mse), considering significant p < 0.05 using ANOVA followed by Tukey test. CONCLUSION: Tramadol has effects similar to local anesthetics and, when used as adjuvant of lidocaine, prolongs motor block duration in rats. Keywords: Lidocaine, Nervous block, Tramadol. Evaluation of the addition of tramadol on lidocaine-induced motor block regression time. Experimental study in rats* MÉTODO:Ratos machos da linhagem Wistar, pesando de 250 a 300 g, foram submetidos a bloqueio de nervo ciático guiado por neuroestimulação percutânea. Os animais foram distribuídos em quatro grupos (n = 5 por grupo): lidocaína a 2% (GI), lidocaína a 0,5% (GII), lidocaína a 2% / tramadol 1,25 mg (GIII), e lidocaína a 0,5% / tramadol 1,25 mg (GIV). Foram avaliados tempo de regressão parcial e tempo de regressão completa do bloqueio motor. RESULTADOS: Todos os animais apresentavam bloqueio motor completo no momento do despertar da anestesia, que regrediu completamente durante o período de observação. O tempo de regressão completa do efeito da lidocaína a 2% foi 41 ± 1,71 minutos, lidocaína a 0,5% foi 25,26 ± 0,83 minutos, lidocaína a 2% / tramadol foi 46,06 ± 0,88 minutos e lidocaína a 0,5% / tramadol foi 36,15 ± 1,18 minutos. A associação da lidocaína a 0,5% ao tramadol 1,25 mg foi mais eficaz que lidocaína a 0,5% isoladamente. Os dados são apresentados como média ± erro padrão da média (epm). Considerou-se significativo p < 0,05 usando a ANOVA seguido do teste de Tukey. CONCLUSÃO: Tramadol possui efeitos semelhantes a anestési-cos locais e, quando usado como adjuvante da lidocaína, prolonga a duração do bloqueio motor em ratos. Descritores: Bloqueio nervoso, Lidocaína, Tramadol. INTRODUCTIONTramadol (1-RS, 2RS)-2-[(dimethyl-amine)-methyl]-1-(3 methoxyphenyl)-cyclohexanol hydrochloride is a central action drug sold as a racemic mixture of two enantiomers [(+) and (-) tramadol]. The methyl group in the phenolic part of the mol...
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