Guayule resin is a byproduct of guayule rubber extraction and its commercial utilization could affect favorably the economics of guayule rubber production. A physical and chemical characterization of the resin has been made and degrading effects upon the rubber determined by viscometry, showing that the resin is a rubber prooxidant. This fact could be important in the field of rubber processing aids (peptizers). Coatings based on guayule resin have been developed which compare favorably in properties (abrasion resistance, gloss, drying time, and water resistance) to a commercial product used as control. A brief summary of the literature survey regarding the resin of guayule is also presented in this paper.