This paper reviews the neurobehavioral and developmental effects of fetal drug exposure. The drugs most commonly associated with adverse developmental outcome include alcohol, anticonvulsants (particularly phenytoin and trimethadione), narcotics, and some environmental toxins. Major limitations of studies examining the consequences of prenatal drug exposure on development include inadequate control of other confounding factors, uncertain accuracy of drug histories, and outcome criteria that provide insufficient delineation of subtle developmental delays.
lowed by surgical excision. We suggest the use of chloramphenicol and penicillin for empirical treatment when cystic fibrosis is present. The one reported patient with brain abscess and cystic fibrosis who received medical therapy alone did well IS]. Patients who are improving on a regimen of antibiotic therapy and whose radiographic lesions show regression should be considered for treatment with antibiotics alone to resolution of their disease. Operation would be reserved for those abscesses increasing in size or threatening crucial structures by extension or mass effect.
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