In European and many African, Middle Eastern and Southern Asian populations lactase persistence (LP) is the most strongly selected monogenic trait to have evolved over the last 10,000 years 1 . While LP selection and prehistoric milk consumption must be linked, considerable uncertainty remains concerning their spatiotemporal configuration and specific interactions 2,3 . We provide detailed distributions of milk exploitation across Europe over the last 9k years using c. 7,000 pottery fat residues from >550 archaeological sites. European milk use was widespread from the Neolithic period onwards but varied spatially and temporally in intensity. Surprisingly, comparison of model likelihoods indicates that LP selection varying with levels of prehistoric milk exploitation provides no better explanation of LP allele frequency trajectories than uniform selection since the Neolithic. In the UK Biobank 4,5 cohort of ~500K contemporary Europeans, LP genotype was only weakly associated with milk consumption and did not show consistent associations with improved fitness or health indicators. This suggests other hypotheses on the beneficial effects of LP should be considered for its rapid frequency increase. We propose that lactase non-persistent individuals consumed milk when it became available, but that under particular conditions and microbiological milieux this was disadvantageous, driving LP selection in prehistoric Europe. Comparison of model likelihoods indicates that population fluctuations, settlement density and wild animal exploitationproxies for these driversprovide better explanations of LP selection than the extent of milk exploitation. These findings offer new perspectives on prehistoric milk exploitation and LP evolution.

SignificanceThis study reveals that animal fats preserved in pottery vessels from the United Nations Educational, Scientific and Cultural Organization (UNESCO) World Heritage site of Çatalhöyük recorded the abrupt 8.2-thousand years B.P. climatic event in their hydrogen isotopic compositions. In addition, significant changes are observed in the archaeology and faunal assemblage of the site, showing how the early farming community at Çatalhöyük had to adapt to climate change. Significantly, this contribution shows that individual biomolecules preserved in ancient animal fats can be used to reconstruct paleoclimate records and thus, provides a powerful tool for the detection of climatic events at well-dated onsite terrestrial locations (i.e., at the very settlements where human populations lived).

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Ultrafast laser writing enables fabrication of three-dimensional structures (sub-micron scale) inside the bulk of diamond. High intensities in the focal volume of the laser cause lattice breakdown; as a result, diamond is transformed into a graphitic phase. Laser written graphitic wires embedded in the single crystal diamond find an application for electrodes in diamond detectors. Laser processing of graphitic columns requires a combination of certain parameters, including power, repetition rate, translation speed. Here, we explore the effect of the laser pulse energy on the electrical resistance of laser written graphitic columns that pass through the thickness of a CVD single crystal slab. We introduce a scheme that allows straightforward electrical analysis of the columns in an all-carbon device, without additional processing of the diamond, that allows for rapid optimisation of the laser parameters.

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