Carcinogenic potentialities of podophyllin were investigated by long‐term application of 20% podophyllin suspension in mineral oil to mouse cervix of C3H mice. Cytologic and histologic changes induced by podophyllin were compared with changes induced by a proven carcinogen (3,4 benzpyrene). Some forms of podophyllin‐induced dysplasia resembled benzpyrene‐induced dysplasia. The classical pattern of human carcinoma in situ was seen only in the presence of invasive carcinoma induced by benzpyrene. Variety of lesions resembling radiation effect were induced by podophyllin only. No invasive lesion was encountered with 340 paintings of the cervix with 20% podophyllin in mineral oil. Invasive squamous carcinomas were found after a thread saturated with a 20% podophyllin suspension in mineral oil was inserted in the endocervical canal.
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