Severe fetal cerebral ventriculomegaly, observed in about 1 in 1000 newborns, may result from chromosomal and genetic abnormalities, brain hemorrhage, or congenital infection, but in many cases there is no clear-cut etiology. The condition is associated with a high risk of perinatal death and neurodevelopmental delay in survivors and after prenatal diagnosis many parents choose to have pregnancy termination. However, some parents choose to continue with the pregnancy and in other cases the diagnosis is made at a gestational age at which termination is not a legal option. One option in the management of such cases of severe ventriculomegaly is intrauterine therapy by
Aim of the study: The aim of the study is to analyze correlation between level of troponin T in fetal blood with NIHF and the course of pregnancy.Material and method: The analysis of troponin T level in fetuses blood was conducted in 22 cases of cordocentesis carried out at the Department of Gynecology, Fertility and Fetal Therapy between 2014-2016. There were 15 cordocentesis performed in cases of NIHF undergoing intrauterine therapy and 7 cordocentesis performed in cases of other pathology that have been assigned to the control group.Results: In the study group there were 9 results obtained over a standard 0.308 ng/ml and 6 results below this value. In the control group 5 results were normal and 2 were above norm. In the group of fetuses with NIHF, 89% of cases with elevated levels of troponin T were unsuccessful, while in the group with normal levels 83% of the cases had a successful course. In the control group 100% of normal levels of troponin T had a successful course, and there were 2 cases of elevated levels of troponin T in 1 newborn rated at 3 points in the Apgar score because of respiratory disorders.
Conclusions:Based on the analysis, it appears that the level of troponin T in fetal blood can be a marker providing information on the prognosis and, therefore, the level of cTnT in fetal blood should be measured to determine the degree of heart failure in conjunction with the echocardiography study.
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