Our results suggest that localized hypoxia occurs in regions of thicker ILT in AAA. This may lead to increased, localized mural neovascularization and inflammation, as well as regional wall weakening. We conclude that ILT may play an important role in the pathology and natural history of AAA.
Our computer models showed that the stress within the wall of an abdominal aortic aneurysm and possibly the potential for rupture are as dependent on aneurysm shape as they are on maximum diameter. This information may be important in determining severity of individual abdominal aortic aneurysms and in improving understanding of the natural history of the disease.
The presence of ILT alters the wall stress distribution and reduces the peak wall stress in AAA. For this reason, ILT should be included in all patient-specific models of AAA for evaluation of AAA wall stresses.
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