Objective: The aim of this study was to analyze the effect of salivary proteins (statherin and histatin-1) on demineralized enamel surface and to study changes in texture, magnitude and direction of crystallites and changes in prismatic structure of enamel respectively. Material & Methods: Synchrotron x-ray diffraction technique to determine the variation in degree of crystal orientation (texture). Incisors were demineralized and sectioned to 300-500 microns, rinsed with salivary protein solutions of statherin and histatin separately and in combination with short and full-lengths. A beam spot size of 20μm × 20μm was used to obtain 2D diffraction patterns to distinguish orientation of crystallites. Results: The contour maps as well as the SEM analysis present similar surface properties of the sample treated with STN-21 and the controlled PBS sample. Therefore, STN-21 was found potent in preventing demineralization and restoring surface enamel texture followed by STN-21+HTN-21 and STN43+HTN38. HTN-21 and HTN-38 showed similar demineralization pattern as the controlled demineralized sample. Conclusion: Ranking of demineralization among samples was found to be controlled demineralized > HTN-21 = HTN-38 > STN-43+HTN-38 > STN-21+HTN-21 > STN-21. Developing STN-21 as a therapeutic against dental caries and erosion. Keywords: Enamel, Demineralization, salivary proteins.
Objective: The objective of the study was to compare the mean clinical attachment gain in patients of chronic periodontitis after scaling and root alone versus Azithromycin as an adjunct to scaling and root. Study Design Comparative study Place and Duration: Conducted at Operative Dentistry Department, Azra Naheed Dental College, Lahore for a duration of 4 months from December 2019 to March 2020. Methodology: Total Sixty patients fulfilling the selection criteria were randomly allocated to SRP and SRP+Az groups. In both groups, conventional scaling and root planing was done. In the SRP group placebo capsules were prescribed, while in the SRP+Az group, Azithromycin (500mg) once daily was prescribed for 3 days. Clinical attachment level (CAL) was measured initially and after 5 weeks. Data was analyzed in SPSS version 19.0 using independent sample t-test. Results: Both groups showed gain in CAL compared to baseline. However, SRP+Az group showed significantly more gain in CAL in comparison to SRP group (P value < 0.05). Conclusion: Use of Azithromycin adjunctive to SRP is an effective treatment modality in chronic periodontitis patients. Keywords: Anti‐Bacterial Agents, Azithromycin, Chronic periodontitis, Clinical attachment level, Periodontal Debridement, Scaling and root planing,
Objective: To determine the prevalence of oral mucosal lesions among the patients visiting a dental hospital. Design of the Study: It was a cross-sectional study. Study Settings: This study was carried out at Outpatient Department of Dentistry Combined Military Hospital, Lahore from November 2020 to April 2021. Material and Methods: Clinically all the patients were examined then questioned if there are any habits such as (pan, chewing, alcohol intake and smoking) and questions were also asked about frequency and the period of their habit and time of systemic disease. The screening of the disease was made by taking history and observing the clinical features as per guidelines of WHO. Results of the Study: Total 178 patients were included in this study out of total sample 76 (42.69%) were male and 57.30% females. Out of 178 patients 91(51.12%) had oral mucosal lesions. Out of 91 patients 48 had females with oral lesion with percentage 26.96 of all the screened patients, while 43 male patients had OMLs making 24.15%. Conclusion: The prevalence of oral mucosal lesions was significantly affected by socio-demographic characteristics like sage, gender, occupation, cigarette use, alcohol use and tobacco chewing. Our study has highlighted facts and figures about epidemiology of the oral mucosal lesions that provide help in organizing the future studies about oral health. Keywords: oral mucosal lesions, chewing, alcohol, who, prevalence, smoking, cigarette
Aim: To determine frequency of dental caries in mal-occluded teeth among children 3-11 years of age and compare dental caries in children with mal-occluded teeth Methodology: This cross sectional analytical study using purposive sampling technique was carried out at Dental hospital of Institute of dentistry, CMH Lahore Medical College, Lahore for 09 months After permission from institute of dentistry, CMH Lahore medical college and informed consent form participants or their parents/ guardian, they were included as male and female children aged 3-11 years that attended dental hospital of Institute of dentistry, CMH Lahore Medical College for dental treatment and had mal-occluded teeth. Children with mental, physical disabilities and whose parents/ guardian refused to take part were excluded. Dental caries in mal-occluded teeth of children was examined to report the frequency of dental caries. SPSS version 23 was used for analysis data. Results: Among the total of 330 patients included in the study, dental caries was observed in 260 (78.8%) of patients. Conclusion(s): Significant associations of dental caries were observed in terms of gender and age, monthly income, interventional urgency, and occupation and education status. Higher frequency of dental caries was observed in the upper middle and lower middle class groups. Keywords: Dental caries, Mal-occlusion, Pre-school children, Dental treatment
Objective: The objective of the present study was to determine the effect of non-surgical periodontal therapy on the disease severity in rheumatoid arthritis patients. Methods: Five hundred and twenty arthritis patients were included in the study, using consecutive non-probability sampling from the outpatient department of various public and private hospitals of Pakistan. Patients with periodontitis along with systemic Rheumatoid Arthritis (RA) were included in the study. Clinical parameters taken for the severity of periodontitis were the Gingival recession (GV), Periodontal Pocket Depth (PPD) and Clinical Attachment Loss (CAL). Independent sample t-test was used for significance before and after non-surgical periodontal therapy. Data was presented with mean (standard deviation). Results: The PPD and CAL of Rheumatoid Arthritis patients were found to be decreased significantly following non-surgical periodontal treatment (p value < 0.05), unlike the gingival recession, which did not decrease significantly (p value > 0.05). Conclusion: The PPD and CAL values of periodontal patients with rheumatoid arthritis were significantly reduced after giving non-surgical Periotherapy along with oral hygiene instruction. Keywords: arthritis; gingiva; periodontitis; periodontal pocket
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