Background: Neuromyelitis optica (NMO) is a demyelinating disease associated to the presence of anti-aquaporin 4 (AQP4) antibodies and damage to the optic nerve and spinal cord. Sometimes Steroids do not stop the autoimmune response. Plasma exchange (PE) is a purification technique used to remove high weight molecules (e.g. antibodies), and it has shown efficacy in NMO unresponsive to steroids. However, the roll of PE in optic neuritis (ON) unresponsive to steroids secondary to NMO has been less studied.
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