This paper deals with optimal designs for Gaussian random fields with constant trend and exponential correlation structure, widely known as the Ornstein-Uhlenbeck process. Assuming the maximum likelihood approach, we study the optimal design problem for the estimation of the trend and the correlation parameter using a criterion based on the Fisher information matrix. For the problem of trend estimation, we give a new proof of the optimality of the equispaced design for any sample size (see Statist. Probab. Lett. 2008; 78:1388-1396. We also show that for the estimation of the correlation parameter, an optimal design does not exist. Furthermore, we show that the optimal strategy for conflicts with the one for , since the equispaced design is the worst solution for estimating the correlation. Hence, when the inferential purpose concerns both the unknown parameters we propose the geometric progression design, namely a flexible class of procedures that allow the experimenter to choose a suitable compromise regarding the estimation's precision of the two unknown parameters guaranteeing, at the same time, high efficiency for both.
The present paper deals with the problem of allocating patients to two competing treatments in the presence of covariates or prognostic factors in order to achieve a good trade-off among ethical concerns, inferential precision and randomness in the treatment allocations. In particular we suggest a multipurpose design methodology that combines efficiency and ethical gain when the linear homoscedastic model with both treatment/covariate interactions and interactions among covariates is adopted. The ensuing compound optimal allocations of the treatments depend on the covariates and their distribution on the population of interest, as well as on the unknown parameters of the model. Therefore, we introduce the reinforced doubly adaptive biased coin design, namely a general class of covariate-adjusted response-adaptive procedures that includes both continuous and discontinuous randomization functions, aimed to target any desired allocation proportion. The properties of this proposal are described both theoretically and through simulations.
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