Quinones are a family of bioactive compounds with known antibacterial, antiviral and antiparasitic activity. The capacity of quinoid compounds to accept electrons, due to electron-attracting (or donating) substituents at the quinone moiety, modulates their redox activity upon interaction with biological systems. Nine quinone derivate including three 2-hydroxyl-1, 4-naphthoquinone; three 4,5-and three 4,9-naphthoquinone scaffolds, were synthesized and evaluated against 3D7 and Dd2 Plasmodium falciparum strains and evaluated the oxidative stress. Cell viability was determined MTTrelated colorimetric assay (EZ4u; Biomedical, Austria). Selectivity of these compounds was evaluated by comparing in vitro, of cytotoxicity in human fibroblast and antimalarial activity in Plasmodium falciparum. Peripheral blood mononuclear cells and hemoglobin release from human erythrocytes were evaluated too. Antiplasmodial activity was evaluated by fluorometry methods. In addition, oxidized membrane protein in the malaria parasite was evaluated in vitro by derivatizatión, after treatment at IC 50 values on P. falciparum Dd2 strain. Quinones showed IC 50 values in the micromole range, selectivity indexes for quinones was variable, compounds 2 and 3 showed excellent selectivity. In vitro antiplasmodial activity was showed; this result is an incentive to continue synthesis and studying the quinoid compounds.
In the food industry, food preservation techniques that do not use chemical products are becoming more common. Therefore, the aim of this research was to evaluate the antagonistic activity (antibiosis) of lactic-acid bacterial strains against pathogenic microorganisms. Lactic-acid bacterial strains were isolated from layered cheese and a commercial product (yogurt); and the same was done with pathogenic bacteria solely from layered cheese. The lactic-acid bacterial strains were identified as species from the Lactobacilli family, while the pathogenic bacteria from layered cheese were identified as Micrococcaceae family species (Staphylococcus aureus). Subsequently, in the same culture medium, bacteria of each species were sowed in order to determine the inhibitory activity ability of the Lactic Acid Bacteria (BAL) As a result, the highly antagonistic activity of the Lactobacilli (inhibition halos were larger than 0.5 centimeters in diameter) against isolated pathogenic microorganisms was demonstrated.
Introduction: Identifying the main advances in the pharmacological and clinical management of the pandemic COVID-19 and SARS-CoV-2, the most recent and currently taking lives worldwide, is to priority of the scientific community that to date have rehearsed and joined efforts in order to respond with effective treatments that stop the progression of the viral infection and manage to recover the patient. Objective: To document available information on the effects of the antimalarials chloroquine / hydroxychloroquine and mefloquine in severe acute respiratory syndrome, generated by SARS CoV-2, according to updates of the best scientific evidence, according to the evolution of the epidemic. Material and Methods: Descriptive documentary study consisting of the selection and review of scientific material whose subject is COVID-19 and SARS-CoV-2 based on published evidence from bibliographic sources seeking different therapeutic options to combat the disease at the same time ace necessary preventive measures plough implemented worldwide. The databases consulted were Scopus, Head office Pubmed and Scielo. Results: 132 articles related to the search were obtained in the first instance, of which they were filtered and prioritized by thematic relevance until 60 articles with to broad relationship were located. The largest number of articles was published between 2015 and 2020 (n = 26; 43.3%). It have been shown that the mechanism of today's SARS-CoV-2 is similar to that of SARS-CoV and MERS-CoV, in the same way; they share the symptoms shown by patients with COVID-19 such ace: fever, non-productive cough, dyspnea, myalgia, fatigue, normal or decreased white blood cell counts. Conclusions: The activity of hydroxychloroquine and chloroquine in viruses is the same since the mechanism of action of these two molecules is identical. Given the pandemic, the use of these drugs is suggested in the management of patients with SARS CoV-2 / COVID-19 infection that have no contraindication for their use and the cardiac toxicity derived from these ace to cause of mortality should not be forgotten, due to what therapy must be individualized. The mefloquine is not recommended due to its neurotoxic effect and association with neuropsychiatric adverse reactions.
Abstract-The aim of this study was to know about the considerations of those admitted to the medicalsurgical postgraduate programs at the University of Cartagena. An observational descriptive methodology was implemented using the databases of the Graduate Department of Medicine. It was noted that the largest number of applicants are from the University of Cartagena followed by the University of Sinu, however in the last year 2017 the second place of admissions, corresponded to graduates of the University of Antioquia. Keywords: Faculty of Medicine, Medical specialties, admission.I. INTRODUCTION A selection of specialties implies a transformation from the undifferentiated undergraduate stage to a completely differentiated professional enterprise, where all future efforts would focus on a single specialized field of medical discipline [1].The evolving landscape of the medical field through innovative and creative developments in technologies has a profound impact on the selection of clinical specialties [2]. In addition, socio-economic and organizational factors also strongly influence the dynamics of medical specializations. Over the past 10 years, the medical profession has broadly opened its doors to women and society, undergoing profound changes, such as the 35-hour work week in some European countries [3]. Medical students have not been spared from these changes and only a few are willing to participate in surgical careers, judged by many to be too restrictive and sometimes underestimated [4].Residents who are currently on the road to surgery are primarily those who have had some contact with surgery during their previous training (called "externat" in France). The situation is complex and several factors influence the choice of students for one or another surgical subspecialty (previous contact with the subspecialty, quality of life, possible income, type of activity) [3].Beyond the challenges inherent in educating and training future generations of general surgeons, surgical educators face the potentially daunting task of identifying successful training candidates who may be successful in their programs and are unlikely to drop out. On the other hand, with an emphasis on Colombia, the national supply of medical programs has increased in recent years by just over 150% from 21 % in 1992 to 64 % in 2015. In some cases, the regional supply is growing much more rapidly [5]. From the 288 institutions of higher education (HEI) registered in Colombia, 64 have qualified registries, Decree 1295 [6] and graduate from 3,500 to 4,000 doctors each year approximately [7].In Cartagena there are 3 Universities with qualified registration that offer training in Medicine and each year 300 doctors graduate approximately.The offer of spots for surgical medical specialties in our country is limited, which in addition to having a working register by the Ministry of National Education, must have an adequate infrastructure, qualified teaching resources and practice scenarios for disciplinary training [5, 7,]. In 2015, the Faculty o...
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