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The use of automation has increased in all the fields of the pharmaceutical industry, such as manufacturing and quality control. In the field of in vitro dissolution testing, the fiber-optic system is often considered a promising tool because it allows in situ monitoring of the drug release without manual sampling, liquid transfer, and hence phase separation. This paper evaluates the use of fiber-optic in vitro dissolution testing and presents a technique to compensate for analytical interferences caused by excipients.

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