Colorectal cancer (CRC) is one of the most commonly diagnosed malignant neoplasms. The aim of the study was to evaluate and correlate most important epidemiological and economic indicators of CRC in 11 selected Balkan countries. The number of new CRC cases was 56,960, and the highest 5-year CRC prevalence was in Slovenia, Croatia, and Greece. Age-standardized CRC incidence rates were highest in Slovenia, Serbia, and Croatia, and age-standardized mortality rates were highest in Croatia, Serbia, and Bulgaria. Current Health Expenditure as % of Gross Domestic Product was the highest in Bosnia and Herzegovina and Serbia. The GDP per capita levels have shown positive correlation with the CRC incidence rate and prevalence. Absolute numbers of new and death-related CRC cases and 5-year prevalence in absolute numbers have shown strong positive correlation with GDP in million current US$. It has been shown that various economic indicators can be linked to the rate of incidence and prevalence of the CRC patients in the selected Balkan countries. Therefore, economic factors can influence the epidemiology of CRC, and heavy CRC burden in the Balkan region may be one of the indexes of the economic development.
Considering the fact that mesenteric teratomas are extremely rare tumors, it is difficult to designate a general conclusion for an adequate treatment of patients suffering from them. Complete surgical excision is indicated in order to establish a correct histopathological diagnosis and to relieve the patients of symptoms.
Because of the possible impact of intensive SD to the cross-link between Malassezia yeasts AhR agonists and skin carcinogenesis, we discussed on this matter and reviewed the literature data regarding ARM. In addition to “pathogenic” and “non-pathogenic” Malassezia subtypes based on AhR agonist production, future studies on Malassezia metabolites, their carcinogenic effect in the skin and development of melanoma are needed. If the cross-link between Malassezia AhR agonists and skin carcinogenesis exists, timely prevention of ARM could be done with Malassezia eradication, especially in patients with severe SD.
Background/Aim. The incidence of nodular thyroid disease increases significantly with age as well as the incidence and aggressiveness of thyroid cancers. The aim of this study was to determine if thyroid surgery for geriatric patients is safe in a short hospital stay surgery setting. Methods. In this retrospective study we have analyzed medical histories of all operated geriatric patients (65 years and older) in which a total or hemithyroidectomy was performed in the period from January 2012 to December 2018. Patients with thyroid reoperations and with simultaneous neck dissections were excluded from the study. The analyzed geriatric patients were divided into hemithyroidectomy and total thyroidectomy groups and were paired with two control age groups (20-44 years and 45-64 years), in a numerical ratio of 1: 1: 1. Results. 976 patients were operated of the thyroid diseases, 214 total thyroidectomies and 33 hemithyroidectomies. In all three hemithyroidectomy groups the average hospital stay was 24 hours, in the total thyroidectomy geriatric group 150 of 214 patients (70.1%) spent 24 hours in the hospital. In the geriatric population, incidence of neck swelling and increased drainage output were higher compared to the control group, and thus the need for longer hospitalizations. Comparing the years, it was shown that subjects with each subsequent year of intervention have a 22% lower chance of developing complications, and regarding pathohistological finding benign thyroid hyperplasia is less likely to develop complications compared to malignant hyperplasia. Conclusion. According to our study total thyroidectomy can be safely performed within the concept of a short hospital stay in patients under 65, while in the elderly, hospitalization days may be extended due to more frequent surgical and non surgical complications, while hemithyroidectomy is safe for all age groups.
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