Selective ON-OFF switching of an 8-hydroxyquinoline-derived fluorosensor was observed in the presence of Hg(II). The sensor can be easily synthesized in a straightforward two step procedure, allowing for determination of Hg(II) in pure unbuffered water. The detection limit of the sensor in water at 20 degrees C was determined to be 2.6 microM Hg(II).
Starting from unsaturated carbonyl compounds a mild new cascade reaction involving enolboration, rhodium-catalysed hydroformylation and intramolecular aldol addition in a regio- and diastereoselective fashion leads to cyclic compounds containing highly-functionalised quaternary carbon centres.
The first report of a fluorescence-based assay for the direct measurement of the regioselectivity of a reaction is described herein, developed from the desire to construct a quicker analytical method for the determination of the ratio of regioisomers obtained in the tandem hydroformylation/Fischer indole synthesis. The method allows for extremely rapid acquisition times, as the use of crude reaction mixtures is allowed. The assay is also shown to be overall very reliable, tolerating the presence of various functional groups and proceeding on average with a standard error of measurement comparable to that of NMR. As fluorescence is the only requirement for the employment of this analytical method, countless numbers of target-specific assays can undoubtedly be developed based upon this initial finding
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