For pesticide registration a post
application assessment is made on the safety of any residue remaining
in the edible portion of the treated crop. This assessment does not
typically consider the bioaccessibility of pesticide residues. The
effects of this on potential exposure to incurred difenoconazole residues
passing through the human gastrointestinal tract were studied, including
the impact of commodity processing. It has previously been demonstrated
that solvent extraction methods have the potential to overestimate
the bioaccessible fraction, so in vitro simulated gut systems may
offer a better approach to determine residue bioaccessibility to refine
the risk assessment process. The bioaccessibility of difenoconazole
residues associated with processed rice samples was assessed using
in vitro intestinal extraction and colonic fermentation methods. The
mean bioaccessibility following intestinal digestion was 33.3% with
a range from 13% to 70.6%. Quantification of the colonic bioaccessible
fraction was not possible due to compound metabolism. Mechanical processing
methods generally increased the residue bioaccessibility, while chemical
methods resulted in a decrease. Both mechanical and chemical processing
methods reduced the total difenoconazole residue level by ca. 50%.
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