The strongest susceptibility genes for the development of systemic lupus erythematosus (SLE) in humans are null mutants of classical pathway complement proteins. There is a hierarchy of disease susceptibility and severity according to the position of the missing protein in the activation pathway, with the severest disease associated with C1q deficiency. Here we demonstrate, using novel in vivo models of apoptotic cell clearance during sterile peritonitis, a similar hierarchical role for classical pathway complement proteins in vivo in the clearance of apoptotic cells by macrophages. Our results constitute the first demonstration of an impairment in the phagocytosis of apoptotic cells by macrophages in vivo in a mammalian system. Apoptotic cells are thought to be a major source of the autoantigens of SLE, and impairment of their removal by complement may explain the link between hereditary complement deficiency and the development of SLE.

The aim of the present study was to examine the effects of movement intensity and path linearity on global positioning system (GPS) distance validity and reliability. One participant wore eight 1-Hz GPS receivers while walking, jogging, running, and sprinting over linear and non-linear 200-m courses. Five trials were performed at each intensity of movement on each 200-m course. One receiver was excluded from analysis due to errors during data collection. The results from seven GPS receivers showed the mean (± s) and percent bias of the GPS distance values on the 200-m linear course were 205.8 ± 2.4 m (2.8%), 201.8 ± 2.8 m (0.8%), 203.1 ± 2.2 m (1.5%), and 205.2 ± 4 m (2.5%) for the walk, jog, run, and sprint trial respectively. Walk and sprint distances were significantly different from jogging and running distances (P < 0.05). The GPS distance values on the 200-m non-linear course were 198.9 ± 3.5 m (-0.5%), 188.3 ± 2 m (-5.8%), 184.6 ± 2.9 m (-7.7%), and 180.4 ± 5.7 m (-9.8%) for the walk, jog, run, and sprint trial respectively; these were significantly lower than those for the corresponding values on the linear course (P < 0.05). Differences between all non-linear movement intensities were significant (P < 0.05). The overall coefficient of variation within and between receivers was 2.6% and 2.8% respectively. Path linearity and movement intensity appear to affect GPS distance accuracy via inherent positioning errors, update rate, and conditions of use; reliability decreases with movement intensity.

This study aimed to evaluate the potential association with anthropometry and upper-body pulling strength with sprint kinematics of competitive surfers. Ten competitive male surfers (23.9 ± 6.8 years, 177.0 ± 6.5 cm, 72.2 ± 2.4 kg) were assessed for stature, mass, arm span, ∑ 7 site skinfold thickness, pronated pull-up strength, and sprint paddling performance from a stationary start to 15 m. Pearson correlation analysis, and independent t-tests were used to compare potential differences between the slower and faster group of sprint paddlers. Strong associations were found between relative (total kilograms lifted per athlete mass) upper-body pulling strength and sprint paddling time to 5, 10, and 15 m, and peak sprint paddling velocity (r = 0.94, 0.93, 0.88, 0.66, respectively, p < 0.05) and relative upper-body pulling strength was found to be superior (p < 0.05) in the faster group, with large effect (d = 1.88). The results of this study demonstrate a strong association between relative upper-body pulling strength and sprint paddling ability in surfers. Strength and conditioning coaches working with competitive surfers should implement strength training with surfers, including an emphasis on developing relative strength, because this may have a strong influence on sprint paddling performance.

In quantum mechanics of one dimension it is shown for potentials which become infinite at a point but are continuous elsewhere, that the singularity acts as an impenetrable barrier if the potential is not integrable up to the singularity, but if the potential is integrable the behavior is not essentially different from that of a potential which does not become infinite.

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