(2015) Clinical efficacy and toxicity of radio-chemotherapy and magnetic resonance imaging-guided brachytherapy for locally advanced cervical cancer patients: A mono-institutional experience, Acta Oncologica, 54:9, 1558Oncologica, 54:9, -1566 , cancer-specifi c survival (CCS) and overall survival (OS) were analyzed actuarially and morbidity crude rates were scored using CTCAEv4.0.Results . Mean follow-up was 36 months (range 6 -94). The mean D90 and D98 for HR-CTV was 84.4 Ϯ 9 Gy and 77 Ϯ 8.1 Gy, while for IR-CTV was 69.1 Ϯ 4.3 Gy and 64.8 Ϯ 4.3 Gy, respectively. The mean D2cm ³ for OARs was the following: bladder: 77.3 Ϯ 10.5 Gy, rectum: 65 Ϯ 6.8 Gy, sigmoid: 63 Ϯ 7.9 Gy and intestine: 64.0 Ϯ 9.1 Gy. Three year LC, CSS and OS were: 94%, 85% and 81%. The three-year regional-and distant control rates were 95% and 74%. Node negative patients had signifi cantly higher three-year CSS (100 vs. 72%, p ϭ 0.016) and OS (92 vs. 72%, p ϭ 0.001) compared to node positive ones. Three-year actuarial late Grade Ն 3 morbidity was the following: GI: 8%, GU: 5%, Vaginal: 8%. The frequency of Grade Ն 3 hematological toxicities including anemia/leukopenia/neutropenia/thrombocytopenia were 8.6%/34.7%/24.3%/24.3%, respectively. Conclusion. This large mono-institutional experience builds up further evidences that IGABT in conjunction with RCT should be the standard of care for patients suffering LACC.
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