The Global Alliance for Surgical, Obstetric, Trauma and Anaesthesia Care (G4 Alliance, http://www.theg4alliance.org/) is thepreeminent global surgery advocacy organization (1) dedicated to eliminating disparities in surgical care around the world. A coalitionof over 60 non-profit organizations, professional societies, academic centers, and other groups, the G4 Alliance represents civil societyinterests in global surgery from the grassroots to the international level. The organization convenes its membership to address commoninterests and concerns, facilitates knowledge and resource sharing, builds consensus and alignment, and conducts outreach withmultilateral organizations, donors, and other global health programs and advocacy initiatives. In a sector characterized by diverseactors and fragmentation of care delivery, scholarship, and funding (2,3), the G4 Alliance provides communication and coordinationaround a common surgical and health system strengthening agenda. The purpose of this paper is to highlight the multiple organizationsthat specifically contribute to neurosurgical advocacy within the G4 Alliance.