Introduction. To date, Рalivizumab is the only approved monoclonal antibody preparation used to prevent the development of respiratory syncytial virus (RSV) infection. The aim of the work is to evaluate the benefits of immunization with Palivizumab in premature infants with bronchopulmonary dysplasia in a day hospital of the Federal Center. Materials and methods. One hundred seven infants of different gestational age at birth were immunized with Palivizumab in the day patient department of hospital-replacing technologies. The preparation was administered to infants at risk for the formation of severe consequences of an RSV infection. Results. Of the 107 children hospitalized in the day hospital, 74 premature babies were diagnosed with bronchopulmonary dysplasia (69%). Before immunization all infants were consulted by pediatrician, pulmonologist, and if necessary, other specialists. Discussion. The length of stay of children in a day hospital ranged from 2 to 3.5 hours on average. Each child stayed with their parents in a separate room. During this time period, the patient received the full range of the services associated with immunization. Conclusion. Thus, immunization with Palivizumab in a day hospital of the Federal Center allows implementing a comprehensive multidisciplinary and individual approach to each infant, without exposing him to an undesirable risk of infection, in compliance with the principle of staged nursing of premature infants for patients with a new form of bronchopulmonary dysplasia who need a long follow-up observation.

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Introduction. To assess the features of the course of new coronavirus infection over the first month of life. Materials and methods. The article presents four clinical cases of coronavirus infection in newborn children aged 8 to 30 days, treated at the covid centre of the National Medical Research Center for Children’s Health. Results. The incubation period lasted from 2 to 10 days. The clinical picture included prevalence of hyperemic palatine arches, lethargy, impaired sucking, hyperemia of the conjunctiva, sneezing, mucous discharge from the nose, cough of varying severity. In more severe cases, an elevation in body temperature, a change in the auscultatory picture of lungs, abnormalities in the electrocardiogram. In the general blood test, there was noted anaemia, relative and absolute neutropenia, lymphocytosis and monocytosis; enlargement of activated partial thromboplastin time, increasing the level of D-dimer in the coagulogram. Computed tomography of the chest showed focal infiltrative changes in the lung tissue or uneven pneumatisation. Conclusion. Our observations show coronavirus infection in newborns, most often to show a mild and moderate course, which does not require the appointment of antibacterial drugs and hormonal, and anticoagulant therapy without strict indications. According to the recommendations of the World Health Organization, the mother, and baby should remain together throughout the day, regardless of the suspicion or confirmation of a viral infection. To date, there is no conclusive evidence mother-to-child transmission of COVID-19 through breastfeeding is possible, and the benefits of breastfeeding far outweigh the minimal risk of infection. In addition, IgA and IgG to SARS-CoV-2, detected in milk, neutralise the effect of the virus.

A review of the literature presents the history of the use of music therapy in the treatment of a variety of diseases, both in adult clinical practice and in neonatology and pediatrics; there are described various musical and therapeutic programs considered as a part of complex, specially developed, methods of non-drug rehabilitation, with the presentation of indications and contraindications for this type of therapy in newborns and infants; possible neurophysiological justifications for the use of melodic and rhythmic support of infants with perinatal pathology are presented, as well as the prospects of using music therapy in the practice of nursing newborns, including premature babies, suffering from combined perinatal pathology, in the structure of restorative treatment (habilitation) of children, as an auxiliary method that mildly potentiates the effects of the main methods: physical and medicinal. Currently, in the leading perinatal centers of the country, the opportunity is being created for babies to listen to music as part of multi-sensory developmental care. Specially processed short fragments of instrumental and vocal works by V. Mozart are used in recording, fragments of works of other classical composers, singing lullabies and folk songs performed by his mother. The reliable potentiating effect of musical therapy on adaptation responses of the immature nervous system is established, the connection of enrichment of the external environment with long-term outcomes of the perinatal lesion is discussed. The combination of tactile kangaroo stimulation with the vocal influence of the mother has been proved to have a greater effect than the use of musical fragments in recording, and a strictly individual approach is needed to use music therapy in premature immature infants to avoid undesirable consequences.