The transcytosis of lipids through enterocytes occurs through the delivery of lipid micelles to the microvilli of enterocytes, consumption of lipid derivates by the apical plasma membrane (PM) and then their delivery to the membrane of the smooth ER attached to the basolateral PM. The SER forms immature chylomicrons (iChMs) in the ER lumen. iChMs are delivered at the Golgi complex (GC) where they are subjected to additional glycosylation resulting in maturation of iChMs. ChMs are secreted into the intercellular space and delivered into the lumen of lymphatic capillaries (LCs). The overloading of enterocytes with lipids induces the formation of lipid droplets inside the lipid bilayer of the ER membranes and transcytosis becomes slower. Here, we examined components of the enterocyte-to-lymphatic barriers in newly born rats before the first feeding and after it. In contrast to adult animals, enterocytes of newborns rats exhibited apical endocytosis and a well-developed subapical endosomal tubular network. These enterocytes uptake membranes from amniotic fluid. Then these membranes are transported across the polarized GC and secreted into the intercellular space. The enterocytes did not contain COPII-coated buds on the granular ER. The endothelium of blood capillaries situated near the enterocytes contained only a few fenestrae. The LCs were similar to those in adult animals. The first feeding induced specific alterations of enterocytes, which were similar to those observed after the lipid overloading of enterocytes in adult rats. Enlarged chylomicrons were stopped at the level of the LAMP2 and Neu1 positive post-Golgi structures, secreted, fused, delivered to the interstitial space, captured by the LCs and transported to the lymph node, inducing the movement of macrophages from lymphatic follicles into its sinuses. The macrophages captured the ChMs, preventing their delivery into the blood.
Subject. This article discusses the demographic factor in the economic development of Russia. Objectives. The article aims to assess the demographic situation in the monotowns of Zverevo and Donetsk of the Rostov Oblast both taking into account the industry-specific orientation of their township-forming enterprises, and taking into account the assignment of an advanced-social-economic-development-area status to them. Methods. For the study, we used the descriptive and statistical methods of analysis. Conclusions. The assignment of the status of a Priority Social and Economic Development Area (PSEDA) to the monotowns under consideration did not bring about an improvement in the demographic situation. The industry-specific orientation of the township-forming enterprise does not affect the demographic situation in the monotown. The considered demographic problems of monotowns are relevant and should be taken into account when developing a strategy for the socio-economic development of these institutional entities.
Subject. The article analyzes development trends in certain types of service robots, namely, hybrid UAVs, bionic prosthetic hands, robotic vacuum cleaners. Objectives. We focus on identifying the main trends in the development of certain types of service robots, building dynamic models of their technical indicators and models of dependence of their price and weight on absolute characteristics and technical parameters. Methods. The study employs methods of correlation and multiple regression analysis. The data of the IFR, the Remotely Piloted Aircraft System, and websites of robot manufacturers serve as the informational basis of the paper. Results. The modeling unveils positive correlation between the integrated indicator of the technical level of hybrid UAVs of convertiplane type and the wingspan. The analysis of modern bionic prosthetic hands shows that the developers focus on optimizing the structure of the prosthetic, however, as the functions of the hand improve, the weight of bionic hand increases. The main factors influencing the price of robot vacuum cleaners are their power, weight, and operating hours. Conclusions. The unit price of a complex indicator of the technical level of hybrid UAVs is lower than the corresponding indicator of fixed-wing UAVs, reflecting a greater efficiency of hybrid UAVs. The analysis of technical indicators of robotic prosthetics (using the case of bionic hands) shows that any improvement of functional characteristics leads to deterioration of weight. The analysis of technical and economic indicators of robotic vacuum cleaners reveals a positive correlation between the price and weight, operating hours and power.
Subject. This article explores the development of the mono-industry town's economy and its dependence on the successful operation of the township-forming enterprise. Objectives. The article aims to analyze the sectoral structures of industry of the Federal Districts of Russia, and the Northwestern Federal District, in particular, as well as the Vologda Oblast and mono-cities located in it. Methods. For the study, we used a comparative analysis. Results. The article identifies problems common to the areas under study. Conclusions. To develop mono-industry towns, it is necessary to design and adopt framework programmes, supplemented by targeted measures that take into account the industry specifics.
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