One- and two-compartmental models describe the concentration of the urea, creatinine, and uric acid very effectively, in contrast with phosphorus, in which modeling results are not satisfactory. Although two-compartmental models are more effective, they are much more complicated than one-compartmental models, which justifies using the one-compartmental model for hemodialysis modeling. A two-compartmental model must be used in the case of rebound phenomenon modeling. The total body water values we have obtained are similar to the anthropometrically based values for urea and creatinine and to a lesser degree for uric acid. Distribution volumes for one- and two-compartmental models obtained from patient weight are the simplest coefficients for mathematical models and have sufficient precision as well. The global value of both compartments is slightly greater than the corresponding value for a one-compartmental model. The effectiveness of dialyzers is in practice lower than might be expected on the basis of the data provided by their manufacturers. Urea cellular clearance is two times greater than creatinine and uric acid cellular clearances. The clearance differences are more prominent for the cellular membrane than for artificial semipermeable membranes.
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