The symmetry-breaking enolisation reaction of a mesopiperidine diester using a chiral bis-lithium amide base allows access to alkylated derivatives in highly diastereo-and enantioselective fashion (≥ 98% ee).
A novel route to isobacteriochlorins is developed that allows the stereoselective synthesis of the macrocycle of haem d, and so establishes its absolute configuration 2R,7R.
A general synthetic route to the enantiopure bicyclic cyclopentadienes (S)‐3 and (R)‐3 of the hydrindane series, starting from the Hajos‐Wiechert ketone 4 or its enantiomer is described. Reasons for the excellent face and endo selectivity of cycloadditions and the resulting consequences for chiral recognition are discussed.
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