CONCLUSIONS: u-PAR and EGFR in serum of patients with clinical suspicion of prostate cancer might provide clinically relevant informations about the state of the prostate gland. The mesurement of serum EGFR could help to predict patients with prostate cancer, while serum uPAR overexpression seems to be related to tumor extraprostatic spread. To our knowledge this is the first report on serum EGFR overexpression in prostate cancer patients.
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