Categorizing suspected cerebrospinal fluid infections as contaminants, colonization, suspected or confirmed VRIs, or ventriculitis more accurately describes the patient's clinical condition and may indicate different management strategies. A prospective, randomized clinical trial is required to further evaluate the efficacy of prophylactic catheter exchange in limiting the incidence of VRIs during prolonged catheterization. Although prophylactic catheter exchange remains a practice option, the available data suggest that this procedure is not currently justified.

Background: The aim of this study was to investigate the existence of associations between bruxism and psychic and occlusal factors. Methods: Participants in this study (n=85) were recruited from the Section of Odontostomatology, Department of Neuroscience, University of Pisa, Italy. They were split into two groups, bruxers (n=34) and non-bruxers (n=51), on the basis of the presence of both clinical and anamnestical indicators of bruxism. All participants were administered two self-reported validated questionnaires to evaluate mood (MOODS-SR) and panic-agoraphobic (PAS-SR) spectra. A number of occlusal variables (deepbite, cross-bite, open-bite, mediotrusive and laterotrusive interferences, slide RCP-ICP, laterotrusive guides, canine and molar classes) were also recorded. Results: With regards to occlusal factors, the only association was revealed between bruxism mediotrusive interferences (p<0.05). As for psychiatric investigation, significant differences between bruxers and controls emerged for the presence of both depressive (p<0.01) and manic symptoms (p<0.01) in MOODS-SR, and for stress sensitivity (p<0.01), anxious expectation (p<0.05), and reassurance sensitivity symptoms (p<0.05) in PAS-SR. In particular, both mood (p<0.01) and panic-agoraphobic (p<0.05) spectra symptoms seem to differentiate bruxers from controls in males, while in females strong differences emerged for stress sensitivity symptoms (p<0.05). Conclusions: It can be confirmed that certain psychic traits are present in bruxers, while occlusal factors are not useful parameters to discern bruxers from non-bruxers.

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The purpose of this study was to investigate for difference in the prevalence of mood disorders between patients with different painful temporomandibular disorders (TMD). After a sample size necessary for the study was calculated, 60 patients with a painful TMD were selected and divided into the following groups: myofascial pain (n=20), temporomandibular joint (TMJ) pain (n=18), combined myofascial and TMJ pain (n=22). Two distinct comparison groups were selected: subjects with a nonpainful TMD (n=25) and TMD-free subjects (n=29). All participants filled out a self-report validated instrument (MOODS-SR) to evaluate psychopathological symptoms related to mood disturbances. A one-way analysis of variance (ANOVA) with Bonferroni's post hoc test for multiple comparisons was performed to investigate for significant differences among the groups. The three groups of patients with painful TMD scored significantly higher than comparison groups in all MOODS-SR domains investigating depression, but no difference was shown between subjects with myofascial pain and those with TMJ pain. No significant differences among the groups emerged for the presence of manic symptoms, indicating that depressive disorders associated with TMD are not an expression of a more complex manic depressive illness. The study concluded that the presence of depressive symptoms in TMD patients seems to be related to the presence of a painful condition and seems to be unrelated to the location of pain. Furthermore, depressive disturbances in painful TMD patients affect the whole spectrum of depressive psychopathology.