BackgroundIn Italy, on December 2022, COVID-19 vaccination was recommended for children aged 6 months-4 years with frail conditions and for those healthy. The purposes of the survey were to understand parental willingness and hesitancy toward COVID-19 vaccination of children with frail conditions in Italy and related influencing factors.MethodsA cross-sectional survey was performed among 445 parents with a child aged 6 months-4 years with frail conditions who attended a teaching hospital and a public hospital randomly selected in the city of Naples, Italy.ResultsAlmost one third (29.9%) were willing to vaccinate their frail children against COVID-19, whereas 21.3% were uncertain, and 48.8% did not intend to vaccinate. Parents with a higher level of perception that the vaccine is useful and safe and those who had received information by pediatrician were more likely to be willing to vaccinate their child. The mean Parent Attitudes About Childhood Vaccines (PACV-5) score was 3.4, with 13.5% of parents high-hesitant for the COVID-19 vaccination for their child. Parents with a higher COVID-19 vaccine-related safety concerns, those who have delayed at least one shot of a recommended vaccine for their child, and those who did not have received at least three doses of the vaccine against SARS-CoV-2 were more likely to be high-hesitant.ConclusionThe survey findings have important implications for designing interventions to increase willingness and to reduce hesitancy for COVID-19 vaccine among parents of frail children aged 6 months-4 years in Italy.

Most of the available literature has shown that gambling disorder (GD) is often associated with several psychiatric conditions. Comorbidities with mood disorders, impulsiveness, personality traits, and impairments in cognitive function have also been frequently investigated. However, it is currently uncommon to study this disorder in individuals without comorbid substance abuse; therefore, the primary aim of our study was to compare the psychological profile of individuals with GD with and without substance use disorder. A total of 60 participants (100% male), including 20 individuals with GD, 20 substance-dependent gamblers (SDGs), and 20 healthy controls (HCs), were assessed with several clinical measures to investigate impulsivity, hostility, mood, and personality traits, as well as with cognitive tasks (i.e., decision-making tasks). Our results showed differences in both experimental groups compared with the HC group in mood disorders, impulsivity, and hostility traits. The ‘‘pure’’ GD group differed from the SDG group only in characteristics related to mood disorders (e.g., State-Trait Anxiety Inventory-Y2, Beck Depression Inventory-II, and assault dimension), whereas greater impairment in decision making processes related to risky choices was shown in the SDG group. This study suggests the importance of studying pure GD to clarify the underlying mechanisms without the neurotoxic effects of the substances. This could provide an important contribution to the treatment and understanding of this complex disorder.