The clinical and immunological responses to typhoid vaccination with parenteral (TAB) and oral (Ty2la) vaccines in two groups of 30 adult male subjects were studied. Parameters monitored included specific anti-Salmonella typhi cell-mediated immunity and total and specific antilipopolysaccharide fecal immunoglobulin A (IgA) titers in Ty2la-vaccinated subjects. Peripheral blood lymphocyte antibacterial activity was significantly increased only in Ty2la-vaccinated subjects. Serum arming activity and results of human F(ab')2 anti-IgG and -IgA inhibition tests suggest antibody-dependent cellular cytotoxicity mediated by IgA in those vaccinated with Ty2la. Interestingly enough, the cells of TAB-vaccinated subjects were able to mediate IgG-dependent cellular cytotoxicity, as was observable from the results of blocking experiments. Moreover, total and specific antilipopolysaccharide fecal IgA levels were observed to be significantly increased with Ty2la, up to 8 months post-vaccination schedule. An early-onset, transitory increase in serum IgM rheumatoid factor was also found, exclusively in subjects treated with TAB, and was no longer detectable on day 240. Ty2la was well tolerated and free of side effects, whereas 65% of subjects administered TAB reported fever, headache, malaise, and local tenderness at the injection site. Our data show that the two typhoid vaccines induce different cell-mediated specific immune responses. The role of these responses in protection against Salmonella infection, however, requires further investigation.
R ésu m é : A c t iv it é d e la D -c a r n it in e e t d e s e s d e r iv é s su r lesin f e c t io n s À Tr y p a n o s o m a c h e z le r a t e t la s o u r is
<p>The “discovery” and the revaluation of ancient bridges, mostly abandoned and unused, seem to follow paths that involved in the past other architectural and engineering works, starting from the core of urban centers along the main arterial streets, extending themselves then towards the peripheral and rural areas.</p><p>There is no doubt that the connection between the two banks of a watercourse was necessary not only in rural areas, but also in the urban centers with dissimilarities due to the different traffic flow, the site specificities and the symbolic associated aspects.</p><p>The road network within the extra-urban areas has registered in various epochs different changes, adjustments, connections, insertions, which basically put out of function those bridges whose structures became inadequate with the new demands.</p><p>What happens for numerous roads whose paths can be simply renewed by increasing their cross sections, can not be, instead, applied directly to the antique bridges, which often remain near the new infrastructure, constructed in order to obtain a much more modern and efficient road layout. After the abandonment of the old road network it can happen that the unused streets disappear, leaving the bridge like a isolated work, almost as a sculpture without connections.</p><p>Sometimes the bridge loses also the watercourse, changing in time its river bed, moving on the side of it, favouring the flow.</p><p>The retrieval of antique bridges means also highlighting pieces of disappeared landscapes, which inserted in the territorial context give significance to the memory of the place.</p><p>The study concerns the research of ancient bridges (up to the XIX c.) in Sicily and their representation within the landscapes in which they are embedded.</p><p>After a reconnaissance of the art bridge works in the island it will be studied in particular the “Val Demone” area.</p>
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