Collision with and subduction of an oceanic plateau is a rare and transient process that usually leaves an indirect imprint only. Through a tectonostratigraphic analysis of pre‐Oligocene sequences in the San Jacinto fold belt of northern Colombia, we show the Late Cretaceous to Eocene tectonic evolution of northwestern South America upon collision and ongoing subduction with the Caribbean Plate. We linked the deposition of four fore‐arc basin sequences to specific collision/subduction stages and related their bounding unconformities to major tectonic episodes. The Upper Cretaceous Cansona sequence was deposited in a marine fore‐arc setting in which the Caribbean Plate was being subducted beneath northwestern South America, producing contemporaneous magmatism in the present‐day Lower Magdalena Valley basin. Coeval strike‐slip faulting by the Romeral wrench fault system accommodated right‐lateral displacement due to oblique convergence. In latest Cretaceous times, the Caribbean Plateau collided with South America marking a change to more terrestrially influenced marine environments characteristic of the upper Paleocene to lower Eocene San Cayetano sequence, also deposited in a fore‐arc setting with an active volcanic arc. A lower to middle Eocene angular unconformity at the top of the San Cayetano sequence, the termination of the activity of the Romeral Fault System, and the cessation of arc magmatism are interpreted to indicate the onset of low‐angle subduction of the thick and buoyant Caribbean Plateau beneath South America, which occurred between 56 and 43 Ma. Flat subduction of the plateau has continued to the present and would be the main cause of amagmatic post‐Eocene deposition.
Background
This study aimed to determine the impact of preoperative exposure to intravenous contrast for CT and the risk of developing postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery.
Methods
This prospective, multicentre cohort study included adults undergoing gastrointestinal resection, stoma reversal or liver resection. Both elective and emergency procedures were included. Preoperative exposure to intravenous contrast was defined as exposure to contrast administered for the purposes of CT up to 7 days before surgery. The primary endpoint was the rate of AKI within 7 days. Propensity score‐matched models were adjusted for patient, disease and operative variables. In a sensitivity analysis, a propensity score‐matched model explored the association between preoperative exposure to contrast and AKI in the first 48 h after surgery.
Results
A total of 5378 patients were included across 173 centres. Overall, 1249 patients (23·2 per cent) received intravenous contrast. The overall rate of AKI within 7 days of surgery was 13·4 per cent (718 of 5378). In the propensity score‐matched model, preoperative exposure to contrast was not associated with AKI within 7 days (odds ratio (OR) 0·95, 95 per cent c.i. 0·73 to 1·21; P = 0·669). The sensitivity analysis showed no association between preoperative contrast administration and AKI within 48 h after operation (OR 1·09, 0·84 to 1·41; P = 0·498).
Conclusion
There was no association between preoperative intravenous contrast administered for CT up to 7 days before surgery and postoperative AKI. Risk of contrast‐induced nephropathy should not be used as a reason to avoid contrast‐enhanced CT.
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