Nephrotic syndrome is a pathology characterized by severe proteinuria, hypoalbuminemia, dyslipidemia, and edema. Edema has classically been associated with an alteration of the forces that govern Starling’s principle. However, some proteins eliminated in excess in the urine (proteasuria) can activate the epithelial sodium channel (ENaC), favoring sodium retention and edema. The α- and γ-ENaC subunits are activated by releasing inhibitory segments that favor the probability of channel opening. Some proteases that have been investigated include plasmin, prostasin, transmembrane protease serine 4, cathepsin, and neutrophil elastases. Therapeutic strategies include water and sodium restriction in the diet, appropriate dosing of diuretics (loop, thiazides, or acetazolamide), and in severe cases, mechanical ultrafiltration. Due to the continuous activation of ENaC in nephrotic syndrome, amiloride is an attractive diuretic strategy that has been shown to be effective in some patients with an acceptable safety profile.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.