Background: A recent study from our group identified Hispanic race/ethnicity as an independent predictor of peritoneal carcinomatosis (PC) in gastric cancer. We sought to identify the tumor factors that might contribute to this strong association in Hispanics. Methods: California Cancer Registry data were used to identify patients diagnosed with gastric adenocarcinoma from 2004 to 2014. Logistic regression analyses were performed to determine odds ratios for cancer stage, tumor location, grade, histology, and PC. Results: Of 16,275 patients with gastric adenocarcinoma who met inclusion criteria, 6463 (39.7%) were non-Hispanic White (NHW), 4953 (30.4%) were Hispanic, 1020 (6.3%) were non-Hispanic Black (NHB), and 3915 (23.6%) were Asian/other. Compared to NHW, Hispanics were more likely to have a poorly differentiated grade (65.9% vs. 57.6%; p < .001), signet ring adenocarcinoma (28.1% vs. 17.6%; p < .001) and stage IV (51.9% vs. 45.0%; p < .001) gastric cancer. The proportion of stage IV patients with PC was also significantly higher in Hispanics compared to NHW, NHB, and Asian/other (28.5% vs. 16.6%, 20.5%, and 25.2%, respectively; p < .001). Conclusions: Hispanic ethnicity is an independent predictor of aggressive tumor phenotype and PC. Disproportionate incidence of signet ring adenocarcinoma and PC highlight the need to explore the genomic differences in Hispanic gastric cancer.
ObjectiveTo assess the effect of ‘En Balance’ on blood sugar control and physical activity.MethodsHispanic subjects (n=16 males, 23 females) participated in a 3 month education intervention with baseline and three month assessments of physical activity using the Arizona Activity Frequency Questionnaire. Paired sample t‐tests were used to assess mean changes in physical activity energy expenditure, blood samples, anthropometric measures, and body composition using fan beam dual X‐ray absorptiometry (DXA); Hologic Discovery A (software v. 12.6).ResultsAfter 3 months, there was a significant increase in moderate intensity physical activity energy expenditure (μ=368±894 kcal/day, p<.01) and high intensity physical activity energy expenditure (μ=405±2569 kcal/day, p=.05) compared to baseline, and significant reductions in hemoglobin A1c (−0.90%, p=.01), total cholesterol (−13.44 mg/dl, p=.01), LDL cholesterol (−10.28 mg/dl, p=.03) and waist circumference (−1.52 cm, p=.04).ConclusionCulturally sensitive diabetes education led to significant improvements in moderate and high intensity physical activity energy expenditure and glucose control in this population of Hispanics with diabetes.Funded by: NIH award 5P20MD001632
The purpose of this study was to compare Tanita tetrapolar foot‐to‐foot bioelectrical impedance analysis (Model TBF‐310, Tanita Corporation of America, Arlington Heights, IL; Tanita‐BIA) and fan beam dual‐energy X‐ray absorptiometry (Hologic Discovery A v12.6, Waltham, MA; DXA). Seventy Hispanic diabetic participants (23 male, 47 female; mean age: 53.03 ± 10.32 yrs; mean weight: 81.45 ± 17.65 kg; and mean body mass index: 31.40 ± 6.80 kg/m^2) participated in a three‐month diabetes education follow‐up study. Fat mass (FM), percent fat mass (%FM), and fat free mass (FFM) were compared using both relative and absolute measures of agreement. Relative measures included Pearson's and Spearman's rank correlation coefficients while absolute agreement was assessed using Bland‐Altman analyses and concordance correlation with 95% confidence intervals calculated using a bootstrap resampling of the data. Pearson's (FM: 0.96, %FM: 0.91, and FFM: 0.82), and Spearman's rank (FM: 0.94, %FM: 0.91, and FFM: 0.92) correlation coefficients showed high measures of association. Bland‐Altman and concordance analyses also demonstrated good agreement [FM: 0.93 (95% CI: 0.89, 0.96)], [%FM: 0.86 (95% CI: 0.79, 0.90)], and [FFM: 0.93 (95% CI: 0.89, 0.96)]. Tanita‐BIA may provide valid measures of FM, %FM and FFM in Hispanic diabetics, and could be a convenient and practical approach for assessment in community‐based research. This study was supported in part by grants 03‐00335 from the Centers for Medicare and Medicaid Services and 5P20MD001632 from the National Institutes of Health.
O: To assess effects of diabetes education on dietary changes and plasma lipid profile.M: Hispanic subjects(n=13 F and 13 M, mean age=53.8±12.7) participated in a 3‐month study. Spearman correlation coefficient was used to evaluate correlations between dietary intake and laboratory measurements.R: At baseline, % calories, protein(r=0.408, p=0.038) was correlated with plasma HDL(mg/dL). At 3 months, plasma triglycerides(mg/dL) correlated with protein(g)(r=−0.43, p=0.03), % calories, protein(r=−0.43, p=0.028), and % calories, carbohydrate(r=0.41, p=0.039); plasma HDL was correlated with % calories, total fat(r=0.56, p=0.003), % calories, saturated fat(r=0.48, p=0.012), % calories, monounsaturated fatty acids(r=0.587, p=0.002), supplementary chromium(μg)(r=0.56, p=0.003), % calories, protein(r=−0.57, p=0.002), % calories, carbohydrate(r=−0.67, p=0.0002). A decrease in alcohol(g)(r=−0.46, p=0.02), % calories, alcohol(r=−0.43, p=0.03) and increase in % calories, protein(r=0.39, p=0.046), was associated with a significant increase in plasma HDL. Decrease in alcohol (r=0.44, p=0.025), % calories, carbohydrate (r=0.45, p=0.02), and % calories, alcohol (r=0.45, p=0.02) was associated with a significant decrease in plasma triglycerides.C: Dietary changes were significantly associated with some lipid profile parameters after a 3‐month diabetes education.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.