The BioFire FilmArray GI Panel was associated with better detection of pathogens than historical controls while also allowing prompt and accurate diagnosis and potential treatment. A higher proportion of viral pathogens compared with historical assumptions was identified as well as mixed infections with multiple pathogens, a phenomenon largely unknown to clinicians before this technology became available.

We present two Delta (B.1.617.2) vaccine breakthrough individuals, a father and son living in separate households. The older, 63-year-old patient's symptoms were severe enough to require hospitalization. Despite having a high titer of anti-spike IgG in his serum, his symptoms resolved within 24 hours following monoclonal antibody (bamlanivimab/etesevimab) therapy.

Author Contributions: Drs Patel and Rendel had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

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Сведения об авторах: Рогова Мария Михайловна-аспирант отдела клинической электрофизиологии и рентгенохирургических методов лечения нарушений ритма и проводимости сердца НИИ кардиологии им. А.Л. Мясникова РКНПК Миронова Наталия Александровна-к.м.н., научный сотрудник того же отдела Родионова Екатерина Сергеевна-аспирант того же отдела Малкина Татьяна Анатольевна-к.м.н., научный сотрудник того же отдела Зыков Кирилл Алексеевич-д.м.н., руководитель лаборатории иммунопатологии сердечно-сосудистых заболеваний НИИ кардиологии им. А.Л. Мясникова РКНПК Беспалова Жанна Дмитриевна-к.м.н., руководитель лаборатории синтеза пептидов НИИ экспериментальной кардиологии РКНПК Бибилашвили Роберт Шалвович-к.ф.-м.н., руководитель лаборатории генной инженерии НИИ экспериментальной кардиологии РКНПК Ефремов Евгений Евгеньевич-к.б.н., руководитель лаборатории иммунохимии НИИ экспериментальной кардиологии РКНПК Голицын Сергей Павлович-д.м.н., профессор, руководитель отдела клинической электрофизиологии и рентгенохирургических методов лечения нарушений ритма и проводимости сердца НИИ кардиологии им. А.Л. Мясникова РКНПК

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By means of computer simulation has been built polypeptide antigen conformational structure that imitates the immunodominant epitope of the 2nd extracellular loop of β1-adrenoreceptor. A linear 25-membered peptide corresponding to calculated sequence was synthesized by means of solid-phase methoyd using Fmoc-technology, then directed by the closure ofdisulfide bridges was obtained original bicyclic polypeptide corresponding to the proposed structure of the conformational antigen. With the help of high-resolution NMR spectroscopy 3D structure of synthetic conformational antigen was investigated. It was shown that the structure of the bicyclic polypeptide similar to that of building computer model. Bicyclic conformational antigen was suitable for the detection of autoantibodies in the blood serum of patients with rhythm and conductivity violation without evidence of organic disease of the cardiovascular system.

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