Background: COVID-19 is an infectious disease caused by SARS-CoV-2 associated with haematological manifestations (thrombolytic events). Aims: Considering the high prevalence of the thrombotic scenarios associated with COVID-19, the aim of this study was to perform a systematic review of the available literature, concerning the relation of COVID-19 and the thrombotic events, and identify prognostic factors for these events. Materials & Methods: PubMed, Web of Science and Scopus databases were searched. Independent reviewers conducted all flow diagram steps. For qualitative analysis, Oxford level of evidence and Newcastle-Ottawa scale were used in the eligible articles. For the prognostic factors, a meta-analysis was conducted to age, number of neutrophils and platelets, and levels of ferritin, C-reactive protein, lactate dehydrogenase and D-dimer. Publication bias was accessed by funnel plot and by trim-and-fill test. Trim-and-fill test was also applied to evaluate meta-analysis bias. Results: Twenty articles were included in the qualitative analysis, and 6 articles were included in the meta-analysis. Case-control studies showed bias related to exposure, and the main bias in cohort studies were related to selection and outcome. All articles received score 4 for the level of evidence. Hypertension and diabetes were the comorbidities more frequently associated with thrombolytic events. Significant results were found regarding D-dimer (P < .0001) and age (P = .0202) for thrombotic events in patients diagnosed with COVID-19. Conclusion: Patients older than 60 years, with hypertension, diabetes and D-Dimer values above 3.17 µg/mL, can be considered prognostic factors for developing thrombotic events due to COVID-19.

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meningocele is preferred. It is characterized by an accumulation of CSF within the abnormally enlarged nerve sheath in the perioptic area. There is no clear information about its etiopathogenesis. It is most commonly associated with neurofibromatosis type 1. It usually manifests itself with blurred vision and headache but can also be detected incidentally. [8][9][10] The most important and reliable method used in diagnosis is MR imaging. Around the optic nerve, it is observed as an area filled with CSF within the aneurysmatic dilatation surrounded by the nerve sheath. The absence of any pathological enhancement and the absence of massive thickness increase in the optic nerve are especially important in differential diagnosis with pathologies such as meningioma and glioma. No additional pathology is seen in idiopathic inflammatory neuroretinitis, but the patient's clinical and examination findings provide a differential diagnosis. Treatment is medical and patients are followed up. However, surgical treatment for decompression of the optic nerve can be applied in patients with progress. 2,5,10 In conclusion, imaging findings have an important place in diagnosis of dural ectasia of the optic nerve sheath without typical symptoms and examination findings. For the definitive and differential diagnosis of the patient, the clinic should be evaluated together with MRI and the patient's treatment should be guided accordingly.

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BackgroundSickle cell disease (SCD) is the most important hemoglobinopathy in terms of frequency and social impact and can affect the stomatognathic system.AimTo assess and compare the developmental defects of the enamel (DDE) in children and adolescents with and without SCD.DesignThis was a cross‐sectional, analytical, and comparative study of 210 children and adolescents aged 5–18 years, who visited the Hematology and Hemotherapy Hospital of Pernambuco.ResultsDevelopmental defects of the enamel were observed in 55.2% of the SCD patients and 35.2% of the non‐SCD patients (healthy group; p < .05). In the SCD group, DDE were more common in females than in males (69.1% vs. 40.0%; p < .05). The incidence of DDE in the permanent teeth was higher in the upper arch than in the lower arch (SCD group, 13.1% vs. 4.6%; healthy group, 8.9% vs. 3.6%; p < .05).ConclusionCompared with the healthy group, the SCD patients were almost twice as likely to develop DDE, mostly affecting females and the permanent teeth. These findings suggest that individuals with SCD need early dental care to avoid future oral problems.