Circulating thyroglobulin antibodies (TgAb) and microsomal antibodies (MsAb) and thyroid function (total and free T4 and T3, TSH basal and after TRH) have been evaluated in 92 hyperprolactinaemic patients (82 females and 10 males; 9 with macroprolactinoma, 22 with microprolactinoma, 4 with acromegaly, 5 with organic lesions of the hypothalamus, 2 with empty sella, 2 with idiopathic hypopituitarism, 2 with primary hypothyroidism, and 46 with idiopathic hyperprolactinaemia). Thyroid function was normal in all cases except 3 with hypothalamic disease and central hypothyroidism, the 2 patients with primary hypothyroidism and 2 with thyrotoxicosis (one due to Graves' disease and one to autonomous thyroid adenoma). High titres of TgAb (\m=ge\1/1250) and/or MsAb (\ m=ge\ 1/1600) were found in the subject with Graves' disease, in one acromegalic, in the 2 primary hypothyroids, and in 12 women with either adenomatous or idiopathic hyperprolactinaemia; low titres of one or both antibodies were found in 9 other euthyroid women and in the one with toxic adenoma. In a control population of 185 subjects studied with the same methods, the prevalence of TgAb and/or MsAb positive (low titres) was 3.3% in females and 2.5% in males. Diffuse thyroid hyperplasia was clinically detectable in 12 euthyroid women and in the one with Graves' disease; 3 others had been previously operated for nodular goitre with histological evidence of Hashimoto's thyroiditis (2 cases) or for a cold nodule; a single thyroid nodule was present in the woman with toxic adenoma and in one euthyroid woman. Most of these subjects also had circulating TgAb and/or MsAb, and a few had increased TSH secretion. No significant differences were found in mean thyroid hormone and TSH levels between euthyroid hyperprolactinaemic subjects and healthy controls, but TRH-stimulated TSH levels were significantly higher in thyroid antibodies positive than negative subjects. These data, in agreement with a few previous reports, suggest that autoimmune thyroid disorders (especially asymptomatic autoimmune thyroiditis) occur in hyperprolactinaemic women with a prevalence far exceeding that observed in many surveys in the general population.The association of autoimmune thyroiditis with prolactinoma has been known for some years (Thorner 1977), but thyroid antibodies were found in that study in only 2 of 38 women, corresponding to the general incidence of circulating thyroid antibodies in the population studied (Tunbridge et al. 1977). Recently, Pelkonen et al. (1982) observed autoimmune thyroiditis in combination with pro¬ lactinoma in 3 of 36 women. The diagnosis of autoimmune thyroiditis was based on the criteria of Gordin et al. (1972), i.e. the presence of circulating microsomal and thyroglobulin antibodies in high titres (> 1/100000 and > 1/25000, respectively). Moreover, the same investigators found exagge¬ rated TSH response to TRH in 4 prolactinoma patients without autoimmune thyroiditis (Pelkonen et al. 1982). It seemed therefore of interest to report our data on thyroi...

Abstract. In 44 euthyroid and goitre-free patients, 23 treated with amiodarone (group A) and 21 treated with other antiarrhythmic drugs (group B), antimicrosomal antibodies and antithyroglobulin antibodies were determined before the beginning of treatment and after 7, 15, 30, 60, and 180 days. In group A, none of the patients had antithyroid antibodies before treatment, 1 of 15 patients (6.7%) had antimicrosomal antibodies (titre 1:100) on day 7 only, and 1 of 18 (5.5%) had antithyroglobulin antibodies (titre 1:80) on day 180. In group B, 1 of 21 patients (4.8%) had antimicrosomal antibodies (IgG class) at titre 1:400 before the beginning of treatment, which was negative on day 180, and 2 of 17 (11.8%) had antimicrosomal antibodies (titre 1:100) on day 60 only. None of these patients showed clinical and/or laboratory signs of hyperor hypothyroidism. These data indicated that antithyroid antibodies rarely appear in amiodarone-treated patients and do not differ significantly from patients treated with other antiarrhythmic drugs. The role of autoimmunity and the meaning of antithyroid antibodies in the pathogenesis of amiodarone-induced thyroid dysfunction (mainly of hypothyroidism) in patients without pre-existent thyroid diseases is still unclear.

1,5mg/dl. A presença de RFA foi definida pela presença de febre mais diagnósticos de trauma, cirurgia recente ou infecção, além de leucopenia ou leucocitose. RESULTADOS: Dos casos, 32,2% foram considerados RFA . Não houve diferença entre os grupos quanto à idade, gênero e cor. Houve pareamento entre os grupos RFA e RFAteta quanto à freqüência de uso de diuréticos (10,1 vs 11,7%) e presença de edema (3 vs 6%). Hipomagnesemia ocorreu em 154 casos (72% do total), sendo 75,9% no grupo RFAteta e 63,8% no grupo RFA (p=0,06). Os níveis de Mg++ (mediana; faixa de variação) foram maiores no grupo RFA : (1,75; 1-3 vs 1,6; 0,9-2,9mg/dl), o mesmo ocorrendo com a glicemia (115; 49-236 vs 99; 61-191mg/dl) e creatinina sérica (0,884 ± 0,306 vs 0,803 ± 0,257mg/dl). Hipermagnesemia foi mais comum no grupo RFA : 8,7 vs 2,1%. CONCLUSÕES: Pacientes RFA apresentam maiores níveis de magnésio sérico, fenômeno possivelmente relacionado com aumentos da glicemia, uréia e creatinina séricas.]]>

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