<p><strong>Background:</strong> Denture stomatitis (DS) is a multifactorial condition that commonly affects denture users and is mainly caused by <em>Candida albicans</em>. Due to the toxic effects of antifungal therapy, new therapies for DS are claimed. <strong>Objective:</strong> The aim of the study was to evaluate the efficacy of aqueous extract of <em>Buchenavia tomentosa</em> and sodium bicarbonate against <em>C. albicans</em> in a model of DS in rats. <strong>Material and Methods:</strong> An acrylic resin device simulating a denture base was fixed covering the palate of forty-eight male rats followed by candidiasis induction. Rats were divided into 4 groups (n=12): Control, sodium bicarbonate, <em>B. tomentosa</em> and nystatin (positive control). Each group was subdivided according to the period of treatment; 24 hours (n=6) and 48 hours (n=6). Animals were sacrificed and had their devices removed for <em>C. albicans </em>counts and SEM analysis. The palate mucosa was removed and processed for histopathologic analysis. <strong>Results: </strong>After 24 hours of treatment, both <em>B. tomentosa</em> and nystatin groups reduced significantly <em>C. albicans </em>counts when compared to control (nystatin x control, p<0.01; <em>B. tomentosa</em> x control, p=0.03). The results were confirmed by the histologic analysis. <strong>Conclusion:</strong> Both the aqueous extract of <em>B. tomentosa</em> and sodium bicarbonate was able to significantly decrease <em>C. albicans</em> counts in an experimental model of DS.</p>
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.