Possible early side-effects of retinoid treatment on bones were studied with the aid of bone-scintigraphy. Isotretinoin treatment (1.0 mg/kg daily for 4 months) was given to 18 patients with acne. Fifteen patients with psoriasis received etretinate treatment (0.7-1.0 mg/kg/day) for 4 months. In the group treated with isotretinoin, pathological uptake of radiolabel was found in three cases, while in the group treated with etretinate, no bone changes attributable to treatment were found. During isotretinoin treatment, a decrease in growth-plate activity was observed. Bone-scintigraphy is considered to be a suitable method for early screening for bone changes occurring in retinoid treatment.

Summary:  Possible side effects of the retinoids etretinate and isotretinoin on the germinal epithelium were examined. 15 men recevietretinate and 13 isotretinoin. After 16 weeks of treatment at therapeutic doses, no changes were observed in fundamental spermatological parameters. On the basis of examinations and data in the literature, we hold the opinion that retinoid treatment is to be considered safe from the andrological viewpoint. Zusammenfassung:  Die mögliche Nebenwirkung von Retinoid (Etretinat und Isotretinoin) auf das Samenepithel wurde an 15 mit Etretinat und an 13 mit Isotretinoin behandelten Männern untersucht. Im Verlauf der 16 Wochen dauernden therapeutischen Behand‐lung in entsprechender Dosis konnten in den grundlegenden Parametern keine Verände‐rungen beobachtet werden. Aufgrund der Untersuchungen und der literarischen Angaben sind wir der Meinung, daß die Behandlung mit Retinoid in andrologischer Hinsicht als si‐cher bezeichnet werden darf.

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