or DDT may be considered from the difference between the effects of PB (l, 2, 8, 12, 33). On the other hand, retinoic acid inhibits the junctional communication between a variety of vertebrate cell types in culture (20, 35) and acts synergistically with a promoter to block intercellular communication ( 15, 22, 25). As various natural or synthetic retinoids have been introduced, the structure-activity relationship is becoming clearer (6, 9, 27, 28, 34 by a common mechanism of toxicity.
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