Background:
Angiotensin Converting Enzyme (ACE) 2 is an important modulator of the
Renin Angiotensin System (RAS) and the RAS plays a central role in renovascular hypertension.
Very few studies investigated the role of components of the counterregulatory RAS axis (ACE2,
Ang-(1-7) and Mas receptor) in renovascular hypertension and the results are controversial.
Objective:
The aim of this study was to investigate the effects of Diminazene Aceturate (DIZE)
administration on renal function and renal inflammation parameters in 2K1C hypertensive rats.
Methods:
Male Wistar rats were divided into three experimental groups: sham-operated animals,
2K1C+saline and 2K1C+DIZE orally (1 mg/kg/day). At the end of the 30 days of treatment, renal
function was analyzed and kidneys from all the groups were collected and processed separately for
measurement of N-acetyl-beta-D-glucosaminidase (NAG) and Myeloperoxidase (MPO) activities,
cytokines, chemokines and nitric oxide levels.
Results:
Oral DIZE administration for 4 weeks in hypertensive rats attenuated renal dysfunction
and reduced the levels of MPO and NAG, cytokines and chemokines (IL1β, IL-6, TNF-α and
MCP-1) and increased urinary nitrate/nitrite levels in 2K1C hypertensive rats.
Conclusion:
Our findings showed that ACE2 activation may effectively improve renal alterations
and inflammation induced by renovascular hypertension.
The results of this solid methodology-based study can help guide surgeons in accurately locating the IOF and AIOF, and consequently, their neurovascular bundles to perform safe procedures during maxillofacial interventions.
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