We report on a female patient with congenital hypothyroidism (CH) missed on a newborn screening test. She is now 10 years old with retarded development. The patient was born premature at 34 weeks of gestation with birth‐weight of 1515 g, and was judged to be normal in the screening programme of Niigata Prefecture. However, she gradually suffered from poor weight gain and retarded development with stridor at breathing. Serum thyroid stimulating hormone (TSH) levels were rechecked and showed high values with normal T3 and T4 levels. She was referred to our hospital at the age of 13 months. She was diagnosed as having CH (ectopic thyroid) with a delayed rise in blood TSH concentration, probably due to the prematurity of the hypothalamic‐pituitary‐thyroid axis. l‐thyroxine therapy brought a decline in TSH levels with partial improvement of her symptoms. Regardless of the result of newborn screening, infants with elevated serum TSH levels should be carefully examined for possible CH, even when T3, T4 and free T4 values are in the normal range.
5-(Hydroxyphenoxymethyl)-2-oxazolidinone (1) and p- or m-bis(2-oxooxazolidin-5-ylmethoxy)benzene (2 or 3) were prepared by the reaction of tris(2,3-epoxypropyl)-1,3,5-triazin-2,4,6(1H,3H,5H)-trione with hydroquinone and resorcinol. These compounds were found by the thermal analysis to be thermally stable. The activation energies of the pyrolysis for 1, 2, and 3 were calculated from the DTA curves to be 142.7, 158.8, and 130.0 kJ mol−1, respectively. The mechanism of the main fragmentation of the linkages between the benzene and oxazolidinone rings by electron impact was found to consist of two processes; a simple cleavage and a rearrangement reaction. Further, each process had the three cleavage modes. In mass spectra of 2 and 3, the fragment ion which corresponded to the molecular ion peak for 1 was detected. High resolution mass spectrometry established the composition of many peaks in the low resolution spectra of the compounds studied.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.