Bipolar diathermy hemorrhoidectomy is quick and bloodless and, although as painful as closed hemorrhoidectomy with the ultrasonic scalpel, is associated with a reduced analgesic requirement immediately after operation.
Safracins A and B, new antibiotics produced by Pseudomonas fluorescens A2-2 , were tested for antitumor activity against mouse tumors . Structurally, these antibiotics belong to the saframycin family of antibiotics, and safracin B is 21-hydroxysafracin A . They showed antitumor activity against L1210 and P388 leukemias and B16 melanoma . The toxic and effective doses of safracin B were much lower than those of safracin A . Safracin B also prolonged the life span of tumor-bearing mice to a greater extent than safracin A . These results indicate that the a-carbinolamine structure plays an important role in the antitumor action of this type of antibiotic. Both safracins were, however, ineffective when their administration route differed from that used for inoculating tumor cells.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.