The synthesis of trifluoromethyl (CF3)- and
pentafluorosulfanyl
(SF5)-substituted cyclopropane-fused γ-lactones was
carried out through Rh2(esp)2-catalyzed intramolecular
cyclopropanation in up to 99% yields. Twelve examples of this interesting
scaffold are reported, as well as postfunctionalizations that provide
access to highly functionalized CF3- and SF5-substituted cyclopropanes. These novel SF5-substituted
analogues join the very short list of available pentafluorosulfanyl
intermediates.
The room temperature synthesis of difluoromethyl-containing compounds using the deoxofluorination reaction of aromatic aldehydes using XtalFluor-E under highly concentrated conditions is described.
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