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In an analysis of data from the CESAME cohort in France, patients with anal and/or perianal Crohn's disease have a high risk of anal cancer, including perianal fistula-related cancer, and a high risk of rectal cancer.

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the appendiceal orifice, which might suggest UC involvement of the appendiceal orifice as the cause of the AM.As only a few cases of UC with an AM have been reported, it remains unknown whether there is a causative link between them. 2,3 Based on our case observation, however, careful follow-up of UC patients with involvement of the appendiceal orifice is warranted due to the possible development of an AM.

Biopsy specimens obtained during EGD with small forceps are as effective for diagnosis as those obtained with standard forceps.