Our findings indicate that high glucose concentrations may stimulate ROS production through PKC-dependent activation of NADPH oxidase, and induce MAP kinase phosphorylation subsequent to proliferation and type I collagen production by HSCs.

The multi-step method can be recommended to reduce the ablation time, and suppress the increase in pressure.

Our data suggested that IL-4 and IL-13 directly affected HSCs by increasing collagen production and suppressing cell proliferation. The anti-fibrogenetic effect of IFN may be due in part to the blockade of IL-4 and IL-13 stimulation of HSCs.

These findings demonstrated that fasudil not only suppresses proliferation and collagen production but also increases collagenase activity.

No abstract