A new class of indanones 4 easily obtained by aryne type condensations, followed by transposition of the benzocyclobutanols 3 thus formed, were transformed into the corresponding oximinopropanolamines 7. These compounds were studied for their potential beta-blocking properties. It was found that 7 have generally low beta 1-blocking properties. Their beta 2-blocking action varies from low to very high. Interestingly one of them (7b) has the highest beta 2 activity/beta 1 activity (343) value known to date.

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Durch Cycloaddition der den Verbindungen (I) entsprechenden Arine mit den Enolaten (II) erhält man die Schlüsselverbindungen (III) und (IV), die über die Phenole (V) in die Phenolether (VI) umgewandelt werden.

Page 2183. Table I. Footnote b should read "The ratio of ED50 (retinoic acid) to ED50 (a test compound), both values having been obtained in concurrent experiments. This is also the case in the other tables." The same is the case in the description of "relative activity" in the Experimental Section (page 2188, left column, lines 35-37).

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