Maleimides are essential compounds for drug conjugation reactions via thiols to antibodies, peptides and other targeting units. However,o ne main drawback is the occurrence of thiol exchange reactions with, for example, glutathione resulting in loss of the targeting ability.A new strategyt oo vercome such retro-Michael exchange processes of maleimide-thiol conjugates by stabilization of the thiosuccinimide via at ranscyclization reactioni s presented. This reaction enablest he straightforward synthesis of stable maleimide-thiol adducts essential in drugconjugation applications.
We report on the hydrothermal polymerization (HTP) of porous polyimide (PI) networks using the medium H2O and the comonomers 1,3,5-tris(4-aminophenyl)benzene (TAPB) and pyromellitic acid (PMA).
Energy storage will be a primordial actor of the ecological transition initiated in the energy and transport sectors. As such, innovative approaches to design high-performance electrode materials are crucial for...
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