The objective of this study was to evaluate the effects of a vertical ladder device for resistance exercises with or without electrical shock stimulus on muscle strength, body composition, limb volume, muscle fibres and plasma lactate and glycemia of female mice. This device is represented by a vertical ladder with electrostimulation. It was analysed in groups of C57BL/6 mice practicing spontaneous physical activity in enriched environment, practicing resisted climbing exercises, practicing resistance exercises with the utility model in question and controls. The acute effects of blood lactate and dark light-box behaviour, and the shortterm chronic effects of muscle strength, limb volume, body composition, muscle fibre area, and central and light-dark quantification were verified. According to the findings, the vertical electrostimulation ladder model presented acute effects on lactate levels, similar to other experimental models of resistance exercise and physical activity. The behaviour in the light-dark box test showed no difference between the groups. Regarding the short-term chronic response, the best results were obtained in the impact-stimulated resistive exercise in the limb traction muscle variables, greater brown adipose tissue weight, greater quadriceps

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OBJETIVO: O objetivo deste estudo foi verificar os efeitos da atividade física em ambiente enriquecido sobre histomorfometria do músculo quadríceps femoral de camundongos C57BL/6 com caquexia associada ao modelo tumoral singênico de melanoma cutâneo. MÉTODOS: Foram utilizados camundongos fêmeas da linhagem C57BL/6 que foram distribuídos aleatoriamente em dois grupos: controle CRC (n=11), que não realizou nenhum tipo de intervenção, o segundo grupo foi o experimental (CRC-ATF) (n=15), que realizou atividade física organizada em ambiente enriquecido de 60 cm de comprimento, 30 cm de largura e 45 cm de altura. Ocorreu indução tumoral de células B16-F10 da linhagem de melanoma cutâneo em todos os animais desse estudo. Após dez dias da indução tumoral, todos os animais já apresentavam quadro de caquexia, assim o grupo experimental iniciou a atividade física em ambiente enriquecido com duração de 30 minutos com intervalos de 48 horas. Após 26 dias do início da intervenção, os animais sobreviventes foram eutanasiados e foi realizada a coleta do músculo quadríceps femoral para análise histomorfométrica. RESULTADOS: Analisando a intervenção realizada, percebemos que o grupo CRC-ATF apresentou a área da fibra muscular maior que o grupo CRC, mas esse resultado não mostrou diferença significativa (p≤0,05) entre os grupos. CONCLUSÃO: Os resultados mostram que é possível preservar a estrutura muscular, pois os melhores resultados foram encontrados com os animais que participaram da atividade física em ambiente enriquecido.

Background: Spatial navigation is a prodromal dementia marker. Exercise used alongside virtual reality improves many cognitive functions, but effects on spatial navigation are still unclear.Objective: To investigate the effect of virtual reality-based physical exercise with 2D exergames on spatial navigation in institutionalized non-robust older persons.Method: A total of 14 older persons (aged ≧ 60) were randomly allocated to the exergame (EG) and active control (ACG) groups. EG performed exercises with 2D exergames, while the ACG used the same movements as the EG, but without the use of virtual reality. Spatial navigation was assessed through the Floor Maze Test, where the immediate maze time (IMT) and delayed maze time (DMT) were recorded.Results: Spatial navigation was enhanced in EG participants compared to ACG individuals. A significant (p = 0.01) IMT reduction between groups was observed, while DMT time without prior planning was significantly different at the significance threshold (p = 0.07).Conclusions: Virtual reality-based exercise improves the spatial navigation of institutionalized non-robust older persons. This study should be replicated to confirm the findings reported herein.Clinical Trial Registration: This study was registered in the Brazilian Registry of Clinical Trials (Protocol RBR-8dv3kg - https://ensaiosclinicos.gov.br/rg/RBR-8dv3kg).

According to our findings, the evaluation of cognitive functions among older persons with frailty and prefrailty provides important complementary information to better manage frailty and its progression.