Dendritic cells (DCs) possess the ability to integrate information about their environment and communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a variety of cell types have been called DCs on the basis of phenotypic and functional attributes. Here, we refocus attention on conventional DCs (cDCs), a discrete cell lineage by ontogenetic and gene expression criteria that best corresponds to the cells originally described in the 1970s. We summarize current knowledge of mouse and human cDC subsets and describe their hematopoietic development and their phenotypic and functional attributes. We hope that our effort to review the basic features of cDC biology and distinguish cDCs from related cell types brings to the fore the remarkable properties of this cell type while shedding some light on the seemingly inordinate complexity of the DC field. Expected final online publication date for the Annual Review of Immunology, Volume 39 is April 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
Effective T cell–dependent immunity to influenza A virus requires recruitment of cDC progenitors to foci of infection via CCR2.
*Autor para correspondênciaRESUMO. Este trabalho teve por objetivo atualizar o profissional de Medicina Veterinária quanto a sua função na Terapia Assistida por Animais (TAA), tendo em vista que é um recurso que está sendo cada vez mais utilizado pela medicina humana como parte do processo terapêutico de diversas doenças humanas, seja emocional, física, cognitiva ou social. A TAA tem como ferramenta principal o animal, maioria das ocasiões o cão, portanto o bem-estar desses animais devem ser mantidos, assim como, sua saúde física e mental. O médico veterinário tem uma responsabilidade importante durante esse momento de terapia, logo é essencial manter a integridade física e emocional do cão, assim também como a realização do seu treinamento com o intuito de fornecer um ambiente calmo e rotineiro tanto para os cães quanto para o paciente humano, buscando o sucesso e resposta positiva, pois além de fazer parte do seu campo de atuação, certos conhecimentos e habilidades práticas são cabíveis e exclusivas do profissional médico veterinário.Palavras chave: Bem-estar, cão, zooterapia Use of animal-assisted therapy as a tool in the treatment of human diseases: Review ABSTRACT. The aim of this study was to update the Veterinary Medicine professional regarding its role in animal assisted therapy (TAA), considering that it is a resource that is increasingly being used by human medicine as part of the therapeutic process of several human diseases, like emotional, physical, cognitive or social. The TAA has the animal as the main tool, most occasions is the dog, therefore the welfare of animals need to be kept as well as their physical and mental health. The veterinarian has an important responsibility during this period of therapy therefore it is essential to maintain the physical and emotional integrity of the dog as well as carrying out his training in order to provide a quiet and routine environment for both dogs in order to find the success and positive response during the treatment. It was concluded that the role of the veterinarian during all the elaboration of the activity of extreme validity, besides being part of its field of action, certain knowledge and practical practices are adequate and exclusive of the veterinarian professional.Key words: Zootherapy, dog, welfare Uso de la terapia asistida por animales como herramienta en el tratamiento de enfermedades de paciente humano: Revisión RESUMEN. Este trabajo tiene por objetivo actualizar el profesional de medicina veterinaria en cuanto a su función en la Terapia asistida por animales (TAA), teniendo en
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