Oral administration of non-steroidal anti-inflammatory drugs (NSAIDs) can lead to adverse effects such as gastrointestinal distress. The complexation of different groups of active substances with b-cyclodextrin (b-CD) has drawn considerable interest over recent years. The purpose of this study was to analyze the ketoprofen/b-cyclodextrin (K/b-CD) conjugate complex as well as to assess its anti-inflammatory effect after oral administration (doses of 30 mg/m 2 and 15 mg/m 2 of body surface), compared with ketoprofen. The studies were done on two models of experimentally-induced acute inflammation in rats (n ¼ 48, 6/group), by means of intraplantar administration of a 10% aqueous kaolin suspension and intraperitoneal administration of a 1% sodium thioglycolate solution. The dynamics of the acute inflammatory process and the anti-inflammatory effects were monitored using plethysmometric determinations after 3, 6, 9, 12, 24 and 48 h (plantar inflammation), and the absorbance of the exudates (spectrophotometrically read) and nucleated cell counts after 24 h (peritoneal inflammation). The coupling of ketoprofen with b-CD resulted in increased solubility (100% in 60 min) of the newly-formed product, which further resulted in a higher bioavailability compared with ketoprofen (<40% in 120 min). In both models of experimentally-induced inflammation, the K/b-CD complex had a higher anti-inflammatory activity than ketoprofen.

Paraplegic patients have always been ideal candidates for physiotherapy due to their body’s inability to recover on its own. Regardless of the cause that led to the onset of paraplegia (traumatic or degenerative), physiotherapy helps these patients with devices and methods designed to restore the proper functioning of their motility, as well as their quality of life. A total of 60 paraplegic dogs without deep pain in the hindlimbs caused by intervertebral disc extrusion or thoracolumbar fractures underwent physiotherapy sessions: manual therapy (massage), electrostimulation (10–20 min with possible repetition on the same day), ultrasound therapy, laser therapy, hydrotherapy, and assisted gait in supportive devices or on treadmills to stimulate and relearn walking, which was the main focus of the study. To maintain the standing position over time, we developed different devices adapted for each patient depending on the degree of damage and the possible associated pathologies: harnesses, trolleys, straps, exercise rollers, balancing platforms and mattresses, physio balls and rollers for recovery of proprioception. The main objective of our study was to demonstrate that physiotherapy and assisted gait in supportive devices to maintain the standing position may help paraplegic dogs to develop spinal walking. Concurrent pathologies (skin wounds, urinary infections, etc.) were managed concomitantly. Recovery of SW was evaluated by progression in regaining the reflectivity, nociception, gait score, and quality of life. After 125 to 320 physiotherapy sessions (25 to 64 weeks), 35 dogs (58.33%) developed spinal walking and were able to walk without falling or falling only sometimes in the case of a quick look (gait score 11.6 ± 1.57, with 14 considered normal), with a lack of coordination between the thoracic and pelvic limbs or difficulties in turning, especially when changing direction, but with the recovery of the quadrupedal position in less than 30 s. The majority of dogs recovering SW were of small size, with a median weight of 6.83 kg (range: 1.5–15.7), mixed breed (n = 9; 25.71%), Teckel (n = 4; 11.43%), Bichon (n = 5; 14.28%), Pekingese (n = 4; 11.43%), and Caniche (n = 2; 5.71%), while those who did not recover SW were larger in size, 15.59 kg (range: 5.5–45.2), and mixed breed (n = 16; 64%).

Bite wounds, human and animal origin, can lead to significant complications if appropriate therapy is not undertaken timeously. The major risk of these aggressions is given by the possibility of systemic propagation of the bacteria involved in the wound and the appearance of complications such as osteomyelitis, septic arthritis, bacterial endocarditis, etc. The identification of pathogenic germs and antibiotic sensitivity test were the key points for a specific therapy that could prevent the spread of infection in the deep tissues. Twenty five biological samples collected from various wounds produced by dogs and cats bites over the veterinary personnel during the medical evaluated. Various aerobic pathogenic and conditional pathogenic bacteria (Staphylococcus aureus, Staphylococcus pseudo intermedius, Staphylococcus intermedius, Staphylococcus epidermidis, Staphylococcus hominis, Staphylococcus xylosus, Staphylococcus warneri, Micrococcus roseus, Streptococcus sp. gr.B, Streptococcus sp. gr.F, Streptococcus sp. gr.G, Enterococcus faecalis, Enterococcus faecium, Trueperella pyogenes, Corynebacterium sp., Bacillus cereus, Pasteurella multocida, Pasteurella canis, Mannheimia haemolitica, Escherichia coli, Pseudomonas aeruginosa, Actinobacillus sp., Neisseria sp) and anaerobic bacteria (Clostridium perfringens, Bacteroides sp.) were isolated. The bacterial drug sensitivity was fluctuating, observing the variations influenced by the natural and acquired resistance of the tested bacterial species. The wounds produced by the bites of dogs and cats have aerobic and anaerobic polymicrobial etiology.

Paralyzed patients have always been ideal candidates for physiotherapy due to their body's inability to recover on its own. Regardless of the cause that led to the onset of paralysis (whether localized or generalized), physiotherapy helps these patients with devices and methods designed to restore their proper functioning of the body, as well as quality of life. Obtaining the standing position is the main stage in the therapeutic process, being the indispensable element for the entire protocol. The present study focused on the devices we developed over time, adapting them for each patient, depending on the degree of damage they presented and the possible associated pathologies. At the same time, we wanted these devices to be available for any therapist or even owner, being made of common materials, easy to find, but also affordable.