A conjuntivite lenhosa é resultante de um raro distúrbio autossômico recessivo hereditário, a deficiência de plasminogênio. Esta apresenta sintomas crônicos, como lesões conjuntivais membranosas características, inicialmente finas e com a persistência da inflamação evoluem se tornando esbranquiçadas, espessas e enrijecidas, lacrimejamento, secreção mucosa e hiperemia ocular acompanhados de espessas pseudomembranas lenhosa (PL) que recobrem a parte interior da conjuntiva tarsal. A literatura apresenta alguns tratamentos, entretanto nenhum deles alcançou a cura da doença. A terapia nutricional abordada neste estudo trata-se da combinação de nutrientes dentro dos limites estabelecidos para ingestão diária, baseada na nutrição ortomolecular, visando ao aumento da taxa de plasminogênio funcional, e a consequente redução dos sintomas associados à sua deficiência. Notou-se o desaparecimento de sintomas associados e redução do crescimento da PL, e também um aumento de 25% do plasminogênio funcional. Um aumento de 25% na dosagem de plasminogênio pode não ser altamente significativo, mas abre um respaldo para maiores estudos, pois já apresentou minimização dos sintomas da paciente.
This is a cross-sectional, prospective, randomized and controlled clinical study approved by the Ethics Committee of the Universidade Federal Fluminense/Hospital Universitário Antônio Pedro (CAAE: 35038014.4.0000.5243). Signed informed consent was obtained from each patient before any study procedure. During six months, every patient with DM attending the outpatient Endocrinology clinic were screened for eligibility. Inclusion criteria were: age older than 18 years; at least one year attending HUAP outpatient clinic. Pregnant women were excluded. All eligible patients willing to participate were included. Socio-demographic, clinical and laboratorial data were obtained during a small interview and from patient´s medical records. Then, patients answered two registered questionnaires (both validated and translated to Portuguese [5-7]. Diabetes Knowledge Scale Questionnaire (DKN-A) and Diabetes Attitudes Questionnaire (ATT-19) [5,6] followed by the intervention. DKN-A has 15 multiple-choice questions: One to twelve have one correct option and questions 13 to 15 have two correct options, and both should be marked for the question to be scored. A score higher than eight indicates a satisfactory knowledge level regarding DM [7]. ATT-19 has 19 questions, and it is measured through a five-point Likert scale. Alternatives reflecting a positive attitude towards DM receive higher scores (five points). A total score higher than 70 indicates positive attitude towards DM [8].Selection of control and intervention groups was carried out in a random way. All the information of each patient was stored in envelopes, which were then sealed. The envelopes were shuffled and selected alternately for each group. The first envelope was for the intervention group. The second was for the control group, and so on. Intervention consisted in a leaflet designed by the research team, using simple language and illustrations based on
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