ObjectiveThe present study sought to analyze the influence of Levetiracetam (LEV) in cognitive performance by identifying the changes produced by LEV in reaction time, in neuropsychological assessment of attention and memory and in absolute theta power in frontal activity.MethodsTwelve healthy subjects (5 men and 7 women; mean age, 30.08 years, standard deviation, 4.71) were recruited for this study. The neuropsychological tests: Trail Making Test (A and B), Digit Span (direct and indirect numerical orders/working memory); Stroop test (inhibitory control of attention); Tower of London (planning and decision-making) and a quantitative electroencephalography were applied in 2 different days after and before the participants ingested the capsule of placebo or 500 mg LEV.ResultsA two-way-ANOVA was implemented to observe the interaction between conditions (placebo or LEV 500 mg) and moments (pre- and post-ingestion of LEV or placebo). The data were analyzed by the SPSS statistical package (p<0.05). For the neuropsychological parameter, the Trail Making Test (A) was the only test that showed significant difference for condition in the task execution time (p=0.026). Regarding the reaction time in the behavioral parameter, an interaction between both factors (p=0.034) was identified through a two-way-ANOVA (condition versus moment). Electrophysiological measures showed a significant interaction for electrodes: F7, F3, and FZ.ConclusionThe findings showed that LEV promotes an important cognitive enhancement in the executive functions.
Bromazepam is a benzodiazepine, which has been widely employed in the treatment of anxiety. We investigated the electrophysiological changes in absolute theta power within the frontal cortex when individuals performed a visuomotor task under bromazepam. The sample of 17 healthy individuals was randomized into 2 experimental conditions, under which bromazepam 6 mg and placebo were administered on different days. All subjects were right -handed, with no mental or physical illness and were not using any psychoactive or psychotropic substance during the entire period of the study. We found an increase in reaction time under bromazepam compared with placebo . With regard to the electrophysiological variable, we found a lower theta power value in the prefrontal cortex prior to task execution, compared with after. We therefore suggested that this could be an increase of neural activity in this region, because of the subjects' readiness to perform the task, that is, because of their higher alertness. The right lateral frontal region showed lower theta power under bromazepam for pre- and post-finger movement. This could have occurred because of more effort to execute the task. In the left frontal region: premovement did not demonstrate any difference between conditions, possibly because the proposed task was simple to execute. In conclusion, theta power plays an important role in the analysis of visuomotor performance, assuming that bromazepam causes impairment on sustained attention and sensory perception.
ObjectiveTo compare head kinematics measurements obtained from 6 different head impact sensors utilizing different methods of sensor-to-head fixation.
DesignFree-drop impacts (total n = 54) were performed at 3.5 and 5.5 m/s onto to the front, back, side, and top of 2 elderly human cadaveric head-neck specimens: a helmeted (Riddell Revolution Speed) male specimen was dropped onto a NOCSAE testing pad; an un-helmeted female specimen was dropped onto a framed sample of field turf. The specimens were instrumented with an intracranial reference sensor surgically mounted at the approximate head center-of-mass by a rigidly-fixed custom standoff pad, an intra-oral test sensor rigidly fixed to the upper teeth/hard palate by a custom orthodontic appliance, and 4 commercially available head impact sensing systems: X-Patch, Vector mouth guard, HITS (helmeted condition only), and G-Force Tracker (affixed to helmet interior or head band depending on helmet status). Peak linear and rotational head accelerations (PLA and PRA) were compared between each sensor and the intracranial reference sensor using intraclass correlation coefficients (ICC [2, 1]).
ResultsAgreement with reference PLA and PRA values differed between sensors, with the greatest agreement observed for the rigidly affixed intraoral sensor (ICC = 0.921, PLA; ICC = 0.810, PRA). Agreement for PLA and PRA, respectively, was: for X-Patch, ICC = 0.638, ICC = 0.155; for Vector mouth guard, ICC = 0.775, ICC = 0.480; for HITS, ICC = 0.662 (PLA only); for G-Force Tracker, ICC = 0.364 (PLA only).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.